(S)-(+)-2-苯甘氨醇合成路线 （共 103 条）
反应条件
1: 66 percent / Na2HPO4 / tetrahydrofuran / 3 h / 25 °C 2: 75 percent / 6N NaOH / methanol / 0.25 h / 60 °C View Scheme
参考文献
Chang, Zen-Yu; Coates, Robert M.
Journal of Organic Chemistry, 1990 , vol. 55, # 11 p. 3464 - 3474
反应条件
1: in chloroform-d1; water-d2 2: With diclazuril in chloroform-d1; water-d2 Further stages.;
参考文献
Tang, Lijun; Choi, Sujung; Nandhakumar, Raju; Park, Flyunjung; Chung, Hyein; Chin, Jik; Kwan, Mook Kim
Journal of Organic Chemistry, 2008 , vol. 73, # 15 p. 5996 - 5999
反应条件
hydrogenchloride; (S)-3,3′-bis[3,5-bis(trifluoromethyl)phenyl]-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate in dichloromethane; water T=21.84°C; pH=2.32; Centrifugal contactor separatorsResolution of racemate; optical yield given as percent ee;
参考文献
Schuur, Boelo; Verkuijl, Bastiaan J.V.; Bokhove, Jeroen; Minnaard, Adriaan J.; De Vries, Johannes G.; Heeres, Hero J.; Feringa, Ben L.
Tetrahedron, 2011 , vol. 67, # 2 p. 462 - 470
反应条件
1: 66 percent / Na2HPO4 / tetrahydrofuran / 3 h / 25 °C 2: 75 percent / 6N NaOH / methanol / 0.25 h / 60 °C View Scheme
参考文献
Chang, Zen-Yu; Coates, Robert M.
Journal of Organic Chemistry, 1990 , vol. 55, # 11 p. 3464 - 3474
反应条件
hydrogenchloride; (S)-3,3′-bis[3,5-bis(trifluoromethyl)phenyl]-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate in dichloromethane; water T=21.84°C; pH=2.32; Centrifugal contactor separatorsResolution of racemate; optical yield given as percent ee;
参考文献
Schuur, Boelo; Verkuijl, Bastiaan J.V.; Bokhove, Jeroen; Minnaard, Adriaan J.; De Vries, Johannes G.; Heeres, Hero J.; Feringa, Ben L.
Tetrahedron, 2011 , vol. 67, # 2 p. 462 - 470
参考文献
Periasamy, Mariappan; Sivakumar, Sangarappan; Reddy, Meda Narsi
Synthesis, 2003 , # 13 p. 1965 - 1967
反应条件
1: Lg-tartaric acid 2: aqueous sulfuric acid; potassium permanganate; aqueous nitric acid View Scheme
参考文献
Reihlen; Knoepfle; Sapper
Justus Liebigs Annalen der Chemie, 1938 , vol. 534, p. 248
反应条件
di-methyltin dichloride in xylene 48 h; Heating;
参考文献
Corey, E. J.; Wang, Zhe
Tetrahedron Letters, 1993 , vol. 34, # 25 p. 4001 - 4004
反应条件
1: 100 °C 2: SOCl2 / 1,2-dichloro-ethane / 55 °C 3: NaOH / ethanol; tetrahydrofuran / 70 °C View Scheme
参考文献
Mueller, Dieter; Umbricht, Gisela; Weber, Beat; Pfaltz, Andreas
Helvetica Chimica Acta, 1991 , vol. 74, # 1 p. 232 - 240
反应条件
in dichloromethane Ambient temperature; Yield given;
参考文献
Mueller, Dieter; Umbricht, Gisela; Weber, Beat; Pfaltz, Andreas
Helvetica Chimica Acta, 1991 , vol. 74, # 1 p. 232 - 240
