(S)-(+)-2-苯甘氨醇合成路线 （共 103 条）
反应条件
1: Na2CO3, n-Bu4NI / tetrahydrofuran / 20 h / Heating 2: MeSO2Cl, Et3N / diethyl ether / 0.5 h / 0 °C 3: Et3N / diethyl ether; H2O / 16 h / Ambient temperature View Scheme
参考文献
De Sousa, Simon E.; O'Brien, Peter; Poumellec, Pierre
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 9 p. 1483 - 1492
反应条件
1: α,α-dimethylmalononitrile; (S)-2-amino-3,3-dimethyl-1-butanol With zinc diacetate in toluene 24 h; Heating; 2: (S)-1-phenyl-2-hydroxyethylamine With zinc trifluoromethanesulfonate in toluene 72 h; Heating;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 15 p. 2270 - 2275
反应条件
1: 97 percent / Et3N / CH2Cl2 / 16 h / 23 °C 2: SOCl2 / 4 h / Heating 3: 0.5 M NaOH / methanol; H2O / 1 h / Heating View Scheme
参考文献
Corey, E. J.; Imai, Nobuyuki; Zhang, Hong-Yue
Journal of the American Chemical Society, 1991 , vol. 113, # 2 p. 728 - 729
反应条件
zinc diacetate in toluene T=110°C; 6 h;
参考文献
Garcia, Jose I.; Mayoral, Jose A.; Pires, Elisabet; Villalba, Isabel
Tetrahedron Asymmetry, 2006 , vol. 17, # 15 p. 2270 - 2275
反应条件
1: α,α-dimethylmalononitrile; (S)-2-amino-3,3-dimethyl-1-butanol With zinc diacetate in toluene 24 h; Heating; 2: (S)-1-phenyl-2-hydroxyethylamine With zinc trifluoromethanesulfonate in toluene 72 h; Heating;
参考文献
Garcia, Jose I.; Mayoral, Jose A.; Pires, Elisabet; Villalba, Isabel
Tetrahedron Asymmetry, 2006 , vol. 17, # 15 p. 2270 - 2275
反应条件
zinc trifluoromethanesulfonate in toluene Heating; Product distribution; Further Variations:Reagents;
参考文献
Cornejo; Fraile; Garcia; Gil; Martinez-Merino; Mayoral; Pires; Villalba
Synlett, 2005 , # 15 art. no. G13005ST, p. 2321 - 2324
反应条件
in dichloromethane 18 h; Heating;
参考文献
Debono, Nathalie; Besson, Michele; Pinel, Catherine; Djakovitch, Laurent
Tetrahedron Letters, 2004 , vol. 45, # 10 p. 2235 - 2238
参考文献
Lukes et al.
Collection of Czechoslovak Chemical Communications, 1958 , vol. 23, p. 1367,1375
反应条件
dihydrogen peroxide; potassium carbonate in ethanol T=50°C;
参考文献
Wu, Yikang; Yang, Yong-Qing; Hu, Qi
Journal of Organic Chemistry, 2004 , vol. 69, # 11 p. 3990 - 3992
反应条件
1: (S)-1-phenyl-2-hydroxyethylamine With sulfuric acid T=0°C; 2 h; 2: potassium ethylxanthate With sodium hydroxide; sulfuric acid T=50°C; pH=9; 9 h;
参考文献
Tetrahedron, , vol. 57, # 43 p. 8939 - 8949
