(S)-(+)-2-苯甘氨醇合成路线 （共 103 条）
反应条件
potassium hydroxide in water T=100°C; 16 h;
参考文献
Chen, Ning; Jia, Weiyi; Xu, Jiaxi
European Journal of Organic Chemistry, 2009 , # 33 p. 5841 - 5846
反应条件
carbon disulfide in potassium hydroxide; hexane; water
参考文献
Synaptic Pharmaceutical Corporation
Patent: US6159990 A1, 2000 ;
US 6159990 A
反应条件
1: (S)-1-phenyl-2-hydroxyethylamine With sulfuric acid T=0°C; 2 h; 2: potassium ethylxanthate With sodium hydroxide; sulfuric acid T=50°C; pH=9; 9 h;
参考文献
Tetrahedron, , vol. 57, # 43 p. 8939 - 8949
反应条件
1: chlorosulfonic acid / acetonitrile / 1 h / Cooling with ice 2: potassium hydroxide / water / 3.5 h / 80 °C View Scheme
参考文献
Chen, Ning; Huang, Zhongyan; Zhou, Chan; Xu, Jiaxi
Tetrahedron, 2011 , vol. 67, # 41 p. 7971 - 7976
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water T=20°C;
参考文献
Reggelin, Michael; Junker, Bernd; Heinrich, Timo; Slavik, Stefan; Buehle, Philipp
Journal of the American Chemical Society, 2006 , vol. 128, # 12 p. 4023 - 4034
反应条件
in 1,4-dioxane; water T=20°C; 16 h;
参考文献
Crestey, Francois; Ottesen, Lars K.; Jaroszewski, Jerzy W.; Franzyk, Henrik
Tetrahedron Letters, 2008 , vol. 49, # 41 p. 5890 - 5893
反应条件
1: 97 percent / molecular sieves 4 Angstroem / tetrahydrofuran / 168 h / 20 °C
2: 67 percent / Pd(PPh3)4; K2CO3; mesityl bromide / dimethylformamide / 5 h / 150 °C
View Scheme
参考文献
Aoyagi, Yutaka; Mizusaki, Toshihiko; Ohta, Akihiro
Tetrahedron Letters, 1996 , vol. 37, # 51 p. 9203 - 9206
反应条件
1: 4-(dimethylamino)pyridine / tetrahydrofuran / 16 h / Ambient temperature
2: Et3N / CH2Cl2 / 1.5 h / 0 °C
3: sodium azide / dimethylformamide / 4 h / 80 °C
4: LAH / tetrahydrofuran / 3 h / -40 °C
View Scheme
参考文献
O'Brien; Sliskovic; Blankley; Roth; Wilson; Hamelehle; Krause; Stanfield
Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1810 - 1822
反应条件
1: 80 percent / molecular sieves 4 Angstroem / tetrahydrofuran / 144 h / 20 °C
2: 65 percent / Pd(PPh3)4; K2CO3; mesityl bromide / dimethylformamide / 2.5 h / 150 °C
View Scheme
参考文献
Aoyagi, Yutaka; Mizusaki, Toshihiko; Shishikura, Masahiro; Komine, Takashi; Yoshinaga, Tokuji; Inaba, Haruko; Ohta, Akihiro; Takeya, Koichi
Tetrahedron, 2006 , vol. 62, # 36 p. 8533 - 8538
反应条件
2-(diphenylphosphinyl)-benzaldoxime; copper(I) oxide; caesium carbonate in acetonitrile
T=80°C; 18 h;
参考文献
Xu, Lei; Zhu, Di; Wu, Fan; Wang, Rongliang; Wan, Boshun
Tetrahedron, 2005 , vol. 61, # 27 p. 6553 - 6560
