1,3-二甲基-8-硝基-1H-嘌呤2,6(3H,9H)-二酮合成路线 （共 17 条）
反应条件
nitric acid; acetic anhydride 1.) 2 h, 2.) 40 deg C, 10 min;
参考文献
Mosselhi; Pfleiderer
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1221 - 1228
反应条件
1: 60 percent / potassium carbonate / dimethylformamide / 1.) 80 deg C, 30 min, 2.) RT 2: 79 percent / sodium ethoxide / 0.25 h / Ambient temperature View Scheme
参考文献
Mosselhi; Pfleiderer
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1221 - 1228
参考文献
Cacace; Masironi
Annali di Chimica (Rome, Italy), 1957 , vol. 47, p. 362,364
反应条件
hydrogenchloride 0.5 h; Heating;
参考文献
Mosselhi; Pfleiderer
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1221 - 1228
参考文献
Cacace; Masironi
Annali di Chimica (Rome, Italy), 1957 , vol. 47, p. 362,364
反应条件
1: 60 percent / potassium carbonate / dimethylformamide / 1.) 80 deg C, 30 min, 2.) RT 2: 43 percent / 1 N NaOH / 0.25 h / 90 °C View Scheme
参考文献
Mosselhi; Pfleiderer
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1221 - 1228
反应条件
water; hydrogen bromide
参考文献
Cacace; Masironi
Annali di Chimica (Rome, Italy), 1957 , vol. 47, p. 362,364
参考文献
Cacace; Masironi
Annali di Chimica (Rome, Italy), 1957 , vol. 47, p. 362,364
反应条件
1: 1.) sodium hydride / 1.) DMF, mineral oil, 90 deg C, 2.) 90 deg C, 3 h 2: 34 percent / sodium hydrosulfite / H2O / 2 h / 80 - 90 °C View Scheme
参考文献
Ueda; Kawabata; Murakami; Nagai; Sakakibara; Goto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 2 p. 270 - 276
反应条件
sodium hydride 1.) DMF, mineral oil, 90 deg C, 2.) 90 deg C, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Ueda; Kawabata; Murakami; Nagai; Sakakibara; Goto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 2 p. 270 - 276
