4-(二溴甲基)-[1,1-联苯]-2-甲腈合成路线 （共 7 条）
反应条件
N-bromosuccinmide; Azo-bis(2,4-dimethyl-valeronitril) in dichloromethane T=45 - 50°C; 2 - 5 h; Industry scale;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1420016 A1, 2004 ;
Location in patent: Page 16; 17-18 ;
反应条件
1: 71 percent / copper(II) oxide; potassium carbonate; potassium fluoride / palladium(II) bromide; 1,10-phenanthroline / quinoline / 24 h / 170 °C 2: 17 percent / N-bromosuccinimide; azobis(isobutyronitrile) / CCl4; cyclohexane / 18 h / 75 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 72, # 19 p. 7473 - 7476
反应条件
1: 72 percent / acetic anhydride; pyridine 2: 71 percent / copper(II) oxide; potassium carbonate; potassium fluoride / palladium(II) bromide; 1,10-phenanthroline / quinoline / 24 h / 170 °C 3: 17 percent / N-bromosuccinimide; azobis(isobutyronitrile) / CCl4; cyclohexane / 18 h / 75 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 72, # 19 p. 7473 - 7476
反应条件
potassium carbonate in acetonitrile T=82°C; 5 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1420016 A1, 2004 ;
Location in patent: Page 16-17 ;
反应条件
potassium hydroxide; phosphonic acid diethyl ester; tri-n-butylmethylammonium chloride in dichloromethane; water T=-5 - 30°C;
参考文献
Miranda, Edgar I.; Vlaar, Cornelis; Zhu, Jingyang
Patent: US2006/41147 A1, 2006 ;
Location in patent: Page/Page column 3-5 ;
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; water; acetic acid in chlorobenzene T=90°C; 11 h;
参考文献
JP2005/82496 A, ;
Page/Page column 13 ;
反应条件
hydrogen; platinum on carbon in n-heptane; water T=60 - 70°C; P=7.35576 - 29.423 Torr;
参考文献
Sumitomo Chemical Company, Limited
Patent: EP1683777 A1, 2006 ;
Location in patent: Page/Page column 5 ;
