2-(2,2,2-三氟-乙酰基氨基)-咪唑并[1,2-a]吡啶-6-羧酸甲酯合成路线 （共 4 条）
反应条件
1: in dichloromethane T=20°C; Reflux; 2: With sodium hydrogencarbonate 0.25 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; BRESSI, Jerome, C.; CHU, Shaosong; ERICKSON, Philip; KOMANDLA, Mallareddy; KWOK, Lily; LAWSON, John, D.; STAFFORD, Jeffrey, A.; WALLACE, Michael, B.; ZHANG, Zhiyuan; DAS, Sanjib
Patent: WO2010/19899 A1, 2010 ;
Location in patent: Page/Page column 126-127 ;
反应条件
in dichloromethane 3 h; Heating;
参考文献
Hamdouchi, Chafiq; Sanchez, Concha; Ezquerra, Jesus
Synthesis, 1998 , # 6 p. 867 - 872
反应条件
1: 93 percent / pyridine / 80 - 90 °C 2: 92 percent / i-Pr2NEt / dimethylformamide / 24 h / 23 °C 3: 49 percent / CH2Cl2 / 3 h / Heating View Scheme
参考文献
Hamdouchi, Chafiq; Sanchez, Concha; Ezquerra, Jesus
Synthesis, 1998 , # 6 p. 867 - 872
反应条件
1: 92 percent / i-Pr2NEt / dimethylformamide / 24 h / 23 °C 2: 49 percent / CH2Cl2 / 3 h / Heating View Scheme
参考文献
Hamdouchi, Chafiq; Sanchez, Concha; Ezquerra, Jesus
Synthesis, 1998 , # 6 p. 867 - 872
