(S)-3-氨基-1-苄基氮杂环庚烷-2-酮合成路线 （共 6 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 2 h;
参考文献
Le Diguarher, Thierry; Ortuno, Jean-Claude; Dorey, Gilbert; Shanks, David; Guilbaud, Nicolas; Pierre, Alain; Fauchere, Jean-Luc; Hickman, John A.; Tucker, Gordon C.; Casara, Patrick J.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 14 p. 3193 - 3204
反应条件
1: 74 g / H2 / Pd-C / ethyl acetate / 8 h 2: 75 percent / potassium hexamethyldisilazide / dimethylformamide; tetrahydrofuran / 0.5 h / 20 °C 3: HCl / ethyl acetate / 1.5 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 48 p. 15394 - 15395
反应条件
1: 12.7 g / N-hydrosuccinimide; DCC / ethyl acetate / 5 h / 20 °C 2: 74 g / H2 / Pd-C / ethyl acetate / 8 h 3: 75 percent / potassium hexamethyldisilazide / dimethylformamide; tetrahydrofuran / 0.5 h / 20 °C 4: HCl / ethyl acetate / 1.5 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 48 p. 15394 - 15395
反应条件
1: 75 percent / potassium hexamethyldisilazide / dimethylformamide; tetrahydrofuran / 0.5 h / 20 °C 2: HCl / ethyl acetate / 1.5 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 48 p. 15394 - 15395
反应条件
1: 75 percent / potassium hexamethyldisilazide / dimethylformamide; tetrahydrofuran / 0.5 h / 20 °C 2: HCl / ethyl acetate / 1.5 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 48 p. 15394 - 15395
反应条件
1.1: 88 percent / aq. NaOH / 2-methyl-propan-2-ol / 12 h / 20 °C 2.1: NaH / tetrahydrofuran / 1 h / 20 °C 2.2: 94 percent / tetrahydrofuran / 2 h / 20 °C 3.1: 95 percent / trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 14 p. 3193 - 3204
