(S)-7-氨基-5-甲基-5,7-二氢-6H-二苯并[b,d]氮杂革-6-酮盐酸盐合成路线 (共 1 条)
反应条件
1: With (2S,3S)-(+)-di-O-(p-toluoyl)-tartaric acid in methanol T=20°C; 8 - 72 h; 2: With sodium hydrogencarbonate in ethyl acetate pH=9 - 10; 3: With hydrogenchloride in methanol
参考文献
Elan Pharmaceuticals, Inc.; Eli Lilly and Company
Patent: US6958330 B1, 2005 ;
Location in patent: Page/Page column 36; 39 ;
US 6958330 B1