2-羟基-5-(三氟甲基)苯甲醛合成路线 （共 9 条）
反应条件
1: in trifluoroacetic acid Heating / reflux; 2: With sulfuric acid in water; trifluoroacetic acid T=25°C; 4 h;
参考文献
Lin, Xu; Doyle, Terrence W.; King, Ivan
Patent: US2004/254103 A1, 2004 ;
Location in patent: Page 9 ;
反应条件
1.1: n-BuLi; TMEDA / -15 °C 1.2: -15 - 20 °C 2.1: aq. HCl View Scheme
参考文献
NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE
Patent: WO2009/133109 A1, 2009 ;
Location in patent: Page/Page column 54 ;
反应条件
1: 3-[4-(trifluoromethyl)phenoyl]tetrahydro-2-H-pyran With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in hexane T=-10°C; 2 h; 2: N,N-dimethyl-formamide in hexane 0.25 h; 3: With hydrogenchloride in hexane
参考文献
Geneste; Schaefer
Synthesis, 2001 , # 15 p. 2259 - 2262
反应条件
1: With 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane 24 h; Reflux; 2: With sulfuric acid in water T=20°C; 4 h;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED; Iwakoshi, Mitsuhiko; Takyo, Hayato
Patent: US2013/90353 A1, 2013 ;
Location in patent: Paragraph 0739 ;
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in water; trifluoroacetic acid; Petroleum ether
参考文献
Knoll Aktiengesellschaft
Patent: US6136825 A1, 2000 ;
反应条件
1: 2-bromo-4-(trifluoromethyl)phenol With n-butyllithium T=-60°C; 2: N,N-dimethyl-formamide
参考文献
Achard, Thierry; Belokon', Yuri N.; Fuentes, Jose A.; North, Michael; Parsons, Teresa
Tetrahedron, 2004 , vol. 60, # 28 p. 5919 - 5930
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/56752 A1, 2006 ;
Location in patent: Page/Page column 31 ;
WO 2006/056752 A1
反应条件
[Pd(η3-1-Ph-allyl)(μ-Cl)]2; cyclohexyl BrettPhos; sodium lauryl sulfate; cesium fluoride in toluene T=110°C; 12 h; Inert atmosphere;
参考文献
Samant, Bhupesh S.; Kabalka, George W.
Chemical Communications, 2011 , vol. 47, # 25 p. 7236 - 7238
反应条件
1.1: 78 percent / HCl / dioxane; CH2Cl2 2.1: n-BuLi; TMEDA / -15 °C 2.2: -15 - 20 °C 3.1: aq. HCl View Scheme
参考文献
Belokon', Yuri N.; Davies; Fuentes, Jose A.; North, Michael; Parsons, Teresa
Tetrahedron Letters, 2001 , vol. 42, # 45 p. 8093 - 8096
