(2S)-3,3-二甲基-2-{2-[(2-甲基-2-丙基)氧基]-2-氧代乙基}丁酸合成路线 （共 4 条）
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran; water T=20°C; Hydrolysis; 72 h;
参考文献
Evans, David A.; Wu, Leester D.; Wiener, John J. M.; Johnson, Jeffrey S.; Ripin, David H. B.; Tedrow, Jason S.
Journal of Organic Chemistry, 1999 , vol. 64, # 17 p. 6411 - 6417
反应条件
1: 82 percent / NaN(SiMe3)2 / tetrahydrofuran / 15 h / -78 °C 2: 85 percent / n-BuLi / hexane; tetrahydrofuran / -78 - 0 °C 3: 100 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 72 h / 20 °C View Scheme
参考文献
Evans, David A.; Wu, Leester D.; Wiener, John J. M.; Johnson, Jeffrey S.; Ripin, David H. B.; Tedrow, Jason S.
Journal of Organic Chemistry, 1999 , vol. 64, # 17 p. 6411 - 6417
反应条件
1: 82 percent / NaN(SiMe3)2 / tetrahydrofuran / 15 h / -78 °C 2: 85 percent / n-BuLi / hexane; tetrahydrofuran / -78 - 0 °C 3: 100 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 72 h / 20 °C View Scheme
参考文献
Evans, David A.; Wu, Leester D.; Wiener, John J. M.; Johnson, Jeffrey S.; Ripin, David H. B.; Tedrow, Jason S.
Journal of Organic Chemistry, 1999 , vol. 64, # 17 p. 6411 - 6417
反应条件
1: 85 percent / n-BuLi / hexane; tetrahydrofuran / -78 - 0 °C 2: 100 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 72 h / 20 °C View Scheme
参考文献
Evans, David A.; Wu, Leester D.; Wiener, John J. M.; Johnson, Jeffrey S.; Ripin, David H. B.; Tedrow, Jason S.
Journal of Organic Chemistry, 1999 , vol. 64, # 17 p. 6411 - 6417
