4-(2-(4-硝基苯基)乙基)吗啉合成路线 （共 11 条）
反应条件
N-ethyl-N,N-diisopropylamine; sodium iodide in acetone T=20°C; 48 h; Product distribution / selectivity;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/18941 A2, 2007 ;
Location in patent: Page/Page column 87 ;
WO 2007/018941 A2
反应条件
in N,N-dimethyl-formamide T=20 - 80°C; 2 h;
参考文献
Reuman, Michael; Beish, Sandra; Davis, Jeremy; Batchelor, Mark J.; Hutchings, Martin C.; Moffat, David F. C.; Connolly, Peter J.; Russell, Ronald K.
Journal of Organic Chemistry, 2008 , vol. 73, # 3 p. 1121 - 1123
反应条件
dimethylsulfide borane complex in tetrahydrofuran T=20°C; 2 h; Heating / reflux; Product distribution / selectivity;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/18941 A2, 2007 ;
Location in patent: Page/Page column 85-86 ;
WO 2007/018941 A2
反应条件
borane in tetrahydrofuran
参考文献
Andrews, Steven W.; Wurster, Julie A.; Wang, Edward H.; Malone, Thomas
Patent: US2003/199478 A1, 2003 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=65°C; 3 h; Product distribution / selectivity;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/18941 A2, 2007 ;
Location in patent: Page/Page column 64 ;
WO 2007/018941 A2
反应条件
zinc in N,N-dimethyl-formamide 24 h; Ambient temperature;
参考文献
Katritzky, Alan R.; Strah, Sonja; Belyakov, Sergei A.
Tetrahedron, 1998 , vol. 54, # 25 p. 7167 - 7178
反应条件
1: water / 20 °C 2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / Reflux View Scheme
参考文献
Wang, Li; Yang, Fenyan; Yang, Xiaochun; Guan, Xianghong; Hu, Chunqi; Liu, Tao; He, Qiaojun; Yang, Bo; Hu, Yongzhou
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 285 - 296
反应条件
1: triphenylphosphine / dichloromethane / 0 °C 2: water / 20 °C 3: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / Reflux View Scheme
参考文献
Wang, Li; Yang, Fenyan; Yang, Xiaochun; Guan, Xianghong; Hu, Chunqi; Liu, Tao; He, Qiaojun; Yang, Bo; Hu, Yongzhou
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 285 - 296
反应条件
1: triethylamine / chloroform / 2.16 h / 20 °C / |Inert atmosphere; |Cooling with ice 2: potassium iodide; N-ethyl-N,N-diisopropylamine / acetonitrile / 9.5 h / 80 - 100 °C / |Inert atmosphere View Scheme
参考文献
TAISHO PHARMACEUTICAL CO., LTD; Kuwada, Takeshi; Yoshinaga, Mitsukane; Ishizaka, Tomoko; Wakasugi, Daisuke; Shirokawa, Shin-ichi; Hattori, Nobutaka; Shimazaki, Youichi; Miyakoshi, Naoki
Patent: US2013/197217 A1, 2013 ;
参考文献
Leffler; Volwiler
Journal of the American Chemical Society, 1938 , vol. 60, p. 896,899
