Z-ALA-PRO-OH合成路线 （共 17 条）
反应条件
acetic acid; 10 palladium on active carbon in methanol Hydrogenation; 2 h;
参考文献
Gudasheva; Vasilevich; Ostrovskaya; Trofimov; Voronina; Skoldinov; Rozantsev
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 9 p. 562 - 567
反应条件
oxygen in acetonitrile
6 h; tyrosinase, phosphate buffer pH 7;
参考文献
Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910
反应条件
triethylamine in water; acetonitrile
T=50°C; 0.0833333 h; Microwave irradiation;
参考文献
Monbaliu, Jean-Christophe M.; Hansen, Finn K.; Beagle, Lucas K.; Panzner, Matthew J.; Steel, Peter J.; Todadze, Ekaterina; Stevens, Christian V.; Katritzky, Alan R.
Chemistry - A European Journal, 2012 , vol. 18, # 9 p. 2632 - 2638
参考文献
Wuensch; Moroder; Gemeiner; et al.
1980 , vol. 35, # 7 p. 911 - 921
反应条件
1: 70 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; HOBt / CH2Cl2 / 0 - 20 °C
2: 66 percent / tyrosinase; phosphate buffer; O2 / H2O; acetonitrile / 6 h / 20 °C / pH 7.0
View Scheme
参考文献
Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910
反应条件
triethylamine in 1,4-dioxane; water
Ambient temperature;
参考文献
Kawasaki; Tsuda; et al.
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 9 p. 2699 - 2706
反应条件
1: 96 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; HOBt; DIPEA / CH2Cl2 / 0 - 20 °C
2: 93 percent / TFA / CH2Cl2
3: 70 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; HOBt / CH2Cl2 / 0 - 20 °C
4: 66 percent / tyrosinase; phosphate buffer; O2 / H2O; acetonitrile / 6 h / 20 °C / pH 7.0
View Scheme
参考文献
Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910
反应条件
1: 70 percent / tyrosinase; phosphate buffer; O2 / H2O; acetonitrile / 5 h / 20 °C / pH 7.0
2: 70 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; HOBt / CH2Cl2 / 0 - 20 °C
3: 66 percent / tyrosinase; phosphate buffer; O2 / H2O; acetonitrile / 6 h / 20 °C / pH 7.0
View Scheme
参考文献
Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910
反应条件
1: 71 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; HOBt; DIPEA / CH2Cl2 / 0 - 20 °C
2: 92 percent / piperidine
3: 70 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; HOBt / CH2Cl2 / 0 - 20 °C
4: 66 percent / tyrosinase; phosphate buffer; O2 / H2O; acetonitrile / 6 h / 20 °C / pH 7.0
View Scheme
参考文献
Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910
反应条件
1: 70 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; HOBt / CH2Cl2 / 0 - 20 °C
2: 66 percent / tyrosinase; phosphate buffer; O2 / H2O; acetonitrile / 6 h / 20 °C / pH 7.0
View Scheme
参考文献
Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910
