2,3,4-三甲氧基苯甲醛合成路线 （共 87 条）
反应条件
1: 21.8 g / 85percent m-chloroperoxybenzoic acid / CH2Cl2 / 5 h 2: K2CO3 / acetone / 17 h / Heating 3: 80 percent / BCl3 / CH2Cl2 / 5 h / Ambient temperature 4: 52 percent / CsF / dimethylformamide / 6 h / 120 °C 5: 87 percent / POCl3 / 48 h / Ambient temperature View Scheme
参考文献
Rizzacasa, Mark A.; Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2017 - 2022
反应条件
1.1: nitric acid; acetic acid / 1.5 h / 0 °C / |Inert atmosphere 2.1: iron; iron sulphate heptahydrate / water; ethanol / 4 h / |Inert atmosphere; |Reflux 3.1: sodium nitrite; hydrogenchloride; 1-phenylphosphoran / water / 0.25 h / 0 - 5 °C / |Inert atmosphere 3.2: 0 - 5 °C / |Inert atmosphere 4.1: dihydrogen peroxide; potassium hydroxide / methanol / 1.17 h / 65 °C 5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / |Inert atmosphere 6.1: dichloromethane / 0.5 h / |Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 135, # 50 p. 18815 - 18823
反应条件
1: mCPBA / CH2Cl2 / 0 - 20 °C 2: aq. NaOH / methanol 3: 95 percent / acetone / 4 h / Heating View Scheme
参考文献
Takahashi, Kimio; Brossi, Arnold; Diseases, Kidney
Heterocycles, 1982 , vol. 19, # 4 p. 691 - 695
反应条件
Yield given. Multistep reaction;
参考文献
Alonso, Ricardo; Brossi, Arnold
Tetrahedron Letters, 1988 , vol. 29, # 7 p. 735 - 738
反应条件
aluminium trichloride in benzene 3 h; Heating;
参考文献
Magnus, Philip; Mitchell, Ian S.
Tetrahedron Letters, 1998 , vol. 39, # 50 p. 9131 - 9134
反应条件
1: With boron trichloride in dichloromethane T=0°C; 5 h; Inert atmosphere; 2: With water in dichloromethane
参考文献
US2012/130129 A1, ;
Page/Page column 12 ;
参考文献
Reichstein et al.
Helvetica Chimica Acta, 1935 , vol. 18, p. 816,826
反应条件
1.1: selenium(IV) oxide; dihydrogen peroxide / tert-butyl alcohol / 1.5 h / 50 °C 2.1: triethylamine / methanol / 0 - 20 °C 3.1: potassium carbonate / acetone / 0 - 20 °C / Inert atmosphere 4.1: trichlorophosphate / 0.33 h / 20 °C 4.2: 6 h / 60 °C 5.1: selenium(IV) oxide; dihydrogen peroxide / tert-butyl alcohol / 2.5 h / 50 °C 6.1: triethylamine / methanol / 0 - 20 °C 7.1: potassium carbonate / acetone / 36 h / 20 °C / Inert atmosphere 8.1: AlCl3, aluminium chloride / dichloromethane / 0 - 20 °C 9.1: lithium hexamethyldisilazane / tetrahydrofuran / -30 - 0 °C / Inert atmosphere 10.1: trifluoroacetic acid / methanol / 24 h / 50 °C 11.1: AlCl3, aluminium chloride; ethanethiol / CHCl2 / 0 - 20 °C View Scheme
参考文献
Chemical Communications, , vol. 47, # 10 p. 2868 - 2870
反应条件
1: piperidine 2: sulfuric acid View Scheme
参考文献
Chemische Berichte, , vol. 73, p. 795,802
反应条件
1: 21.8 g / 85percent m-chloroperoxybenzoic acid / CH2Cl2 / 5 h 2: K2CO3 / acetone / 17 h / Heating 3: 80 percent / BCl3 / CH2Cl2 / 5 h / Ambient temperature 4: 52 percent / CsF / dimethylformamide / 6 h / 120 °C 5: 87 percent / POCl3 / 48 h / Ambient temperature 6: 70 percent / BCl3 / CH2Cl2 / 0.25 h / Ambient temperature View Scheme
参考文献
Rizzacasa, Mark A.; Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2017 - 2022
