2,3,4-三甲氧基苯甲醛合成路线 （共 87 条）
反应条件
potassium hydroxide in ethanol; water
T=60°C;
参考文献
Valdameri, Glaucio; Gauthier, Charlotte; Terreux, Raphael; Kachadourian, Remy; Day, Brian J.; Winnischofer, Sheila M. B.; Rocha, Maria E. M.; Frachet, Veronique; Ronot, Xavier; Di Pietro, Attilio; Boumendjel, Ahcene
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3193 - 3200
反应条件
1: 87 percent / AlCl3 / benzene
2: K2CO3 / acetone / 6 h / Heating
3: 84 percent / AcOH; ethylenediamine / 20 °C
4: 95 percent / LAH / tetrahydrofuran / 24 h / 20 °C
5: Na2CO3 / CH2Cl2; H2O / 2 h / 20 °C
6: 66 percent / POCl3 / dimethylformamide / 3 h / 20 °C
7: 62 percent / sodium hydrogen carbonate / acetonitrile / 18 h / Heating
8: hydrogen / Pd/C / ethyl acetate / 20 °C / 3878.61 Torr
9: NaH / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Ploypradith, Poonsakdi; Petchmanee, Thaninee; Sahakitpichan, Poolsak; Litvinas, Nichole D.; Ruchirawat, Somsak
Journal of Organic Chemistry, 2006 , vol. 71, # 25 p. 9440 - 9448
反应条件
1: ammonium acetate; acetic acid / 12 h / 100 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 80 °C
3: triethylamine / tetrahydrofuran / 24 h / 0 - 20 °C
4: poly-phosphoric acid / 0.17 h / 145 °C
5: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / |Reflux
View Scheme
参考文献
Yang, Su Hui; Song, Chin-Hee; Van, Hue Thi My; Park, Eunsook; Khadka, Daulat Bikram; Gong, Eun-Yeung; Lee, Keesook; Cho, Won-Jea
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3414 - 3418
反应条件
1: 77 percent / zinc oxide / 4 h / 80 °C
2: 82 percent / conc. sulfuric acid / 1.5 h / 3 - 4 °C
3: copper / 0.17 h / 300 °C
View Scheme
参考文献
Rouessac; Leclerc
Synthetic Communications, 1993 , vol. 23, # 19 p. 2709 - 2715
反应条件
1: 21.8 g / 85percent m-chloroperoxybenzoic acid / CH2Cl2 / 5 h
2: K2CO3 / acetone / 17 h / Heating
3: 80 percent / BCl3 / CH2Cl2 / 5 h / Ambient temperature
4: 52 percent / CsF / dimethylformamide / 6 h / 120 °C
View Scheme
参考文献
Rizzacasa, Mark A.; Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2017 - 2022
反应条件
triphenylphosphine in dichloromethane
参考文献
Ding, Yu; Green, James R.
Synlett, 2005 , # 2 art. no. S10504ST, p. 271 - 274
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C
2.1: hydrogen / palladium 10 on activated carbon / methanol / 24 h
View Scheme
参考文献
Tanpure, Rajendra P.; George, Clinton S.; Strecker, Tracy E.; Devkota, Laxman; Tidmore, Justin K.; Lin, Chen-Ming; Herdman, Christine A.; Macdonough, Matthew T.; Sriram, Madhavi; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 24 p. 8019 - 8032
反应条件
1: L. Horner, W. Duerckheimer, K. H. Weber, K. Doelling, Chem. Ber. 97, 312 (1964)
2: boron trichloride
View Scheme
参考文献
Boberg; Kurz; Ploschke; Schmitt; Scholl; Schuller; Wunsche
Arzneimittel-Forschung/Drug Research, 1990 , vol. 40, # 5 p. 555 - 563
反应条件
sodium tetrahydroborate; phosphorus tribromide
1.) MeOH-CH2Cl2, 0 deg C, 5 min, 2.) ether-pyridine, reflux, 2 h; Multistep reaction;
参考文献
Feng, Lianshun; Lv, Kai; Liu, Mingliang; Wang, Shuo; Zhao, Jing; You, Xuefu; Li, Sujie; Cao, Jue; Guo, Huiyuan
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 125 - 136
反应条件
lithium methanolate in methanol; N,N-dimethyl-formamide
T=90°C; 4.5 h;
参考文献
Hewgill, Frank R.; Slamet, Riskiono; Stewart, Jeffery M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 12 p. 3033 - 3042
