3-苯基-1H-吡唑-4-羧酸甲酯合成路线 （共 8 条）
反应条件
in methanol; dichloromethane T=20°C; 0.666667 h;
参考文献
MERCK SHARP and; DOHME CORP.; BURGEY, Christopher, S.; POTTEIGER, Craig, M.
Patent: WO2010/111059 A1, 2010 ;
Location in patent: Page/Page column 54 ;
WO 2010/111059 A1
反应条件
1: 250 mg / diethyl ether 2: 250 mg / 30percent NaOH / Heating View Scheme
参考文献
Kobayashi, Yoshiro; Yamashita, Toshinori; Takahashi, Katsuhiro; Kuroda, Hisashi; Kumadaki, Itsumaro
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 11 p. 4402 - 4409
反应条件
sodium hydroxide Heating;
参考文献
Kobayashi, Yoshiro; Yamashita, Toshinori; Takahashi, Katsuhiro; Kuroda, Hisashi; Kumadaki, Itsumaro
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 11 p. 4402 - 4409
参考文献
v.Auwers; Ungemach
Chemische Berichte, 1933 , vol. 66, p. 1209
参考文献
v.Auwers; Ungemach
Chemische Berichte, 1933 , vol. 66, p. 1209
反应条件
1.) ether, stream of argon, CO2-Dewar vessel - 1day, refrigerator - 1day, room temperature, 10days, 2.) 20 degC, 1day; Multistep reaction;
参考文献
Medvedeva, A. S.; Demina, M. M.; Safronova, L. P.; Kalikhman, I. D.; Vitkovskii, V. Yu.; Vyazankin, N. S.
J. Gen. Chem. USSR (Engl. Transl.), 1983 , vol. 53, # 10 p. 2251 - 2254,2029 - 2032
参考文献
v.Auwers; Ungemach
Chemische Berichte, 1933 , vol. 66, p. 1209
反应条件
in diethyl ether
1 h; Ambient temperature;
参考文献
Kobayashi, Yoshiro; Yamashita, Toshinori; Takahashi, Katsuhiro; Kuroda, Hisashi; Kumadaki, Itsumaro
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 11 p. 4402 - 4409
