2-[(甲氨基)甲基]吡啶合成路线 （共 15 条）
反应条件
hydrogenchloride; sodium tetrahydroborate; methylamine in ethanol; dichloromethane
参考文献
LUCKY LTD.
Patent: EP601486 A1, 1994 ;
反应条件
in ethanol; water 96 h; Ambient temperature;
参考文献
Zara-Kaczian, Erzsebet; Deak, Gyula; Gyoergy, Lajos
Acta Chimica Hungarica, 1989 , vol. 126, # 4 p. 441 - 454
反应条件
titanium tetrachloride; magnesium; mercury dichloride in tetrahydrofuran T=0°C; 12 h; Yields of byproduct given;
参考文献
Mangeney, P.; Tejero, T.; Alexakis, A.; Grosjean, F.; Normant, J.
Synthesis, 1988 , # 3 p. 255 - 257
反应条件
hydrogenchloride in 1,4-dioxane T=40°C; 0.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 3 p. 320 - 330
反应条件
1: 98 percent / CH2Cl2 / Ambient temperature 2: 1.) sodium hydride / 1.) THF, 0 deg C, 15 min, 2.) THF, RT, 2 h 3: HCl / dioxane / 0.5 h / 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 3 p. 320 - 330
反应条件
1: N-(2-pyridylmethyl)formamide With sodium hydride in tetrahydrofuran 0.25 h; Inert atmosphere; 2: methyl iodide With sodium hydroxide in tetrahydrofuran Inert atmosphere;
参考文献
Hitomi, Yutaka; Hiramatsu, Kazuaki; Arakawa, Kengo; Takeyasu, Toshiyuki; Hata, Masashi; Kodera, Masahito
Dalton Transactions, 2013 , vol. 42, # 36 p. 12878 - 12882
反应条件
1: 1.) sodium hydride / 1.) THF, 0 deg C, 15 min, 2.) THF, RT, 2 h 2: HCl / dioxane / 0.5 h / 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 3 p. 320 - 330
反应条件
sodium tetrahydroborate in methanol T=20°C; Inert atmosphere;
参考文献
Hanaoka, Kenjiro; Muramatsu, Yasuaki; Urano, Yasuteru; Terai, Takuya; Nagano, Tetsuo
Chemistry - A European Journal, 2010 , vol. 16, # 2 p. 568 - 572
反应条件
potassium hydroxide in methanol
参考文献
Tetrahedron Letters, , vol. 26, # 48 p. 5863 - 5866
反应条件
1: KH / tetrahydrofuran / 0 °C 2: KOH / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 26, # 48 p. 5863 - 5866
