1H-吡啶并[2,3-d][1,3]噁嗪-2,4-二酮合成路线 (共 18 条)
参考文献
Pratt, John K.; Betebenner, David A.; Donner, Pamela L.; Green, Brian E.; Kempf, Dale J.; McDaniel, Keith F.; Maring, Clarence J.; Stoll, Vincent S.; Zhang, Rong
Patent: US2004/167123 A1, 2004 ;
Location in patent: Page/Page column 70 ;
US 20040167123 A1
反应条件
lead(IV) acetate in N,N-dimethyl-formamide
参考文献
Canonne, P.; Boulanger, R.; Chantegrel, B.
Tetrahedron, 1987 , vol. 43, # 4 p. 663 - 668
反应条件
sodium carbonate in water
参考文献
Sonnenburg, Ralf; Neda, Ion; Fischer, Axel; Jones, Peter G.; Schmutzler, Reinhard
Chemische Berichte, 1995 , vol. 128, # 6 p. 627 - 634
反应条件
trimethylsilylazide in chloroform Title compound not separated from byproducts;
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 24 p. 4692 - 4703
反应条件
(i) NaOMe, (ii) (thermolysis), toluene; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 35, # 5 p. 1471 - 1475
参考文献
PathoGenesis Corporation
Patent: US5441955 A1, 1995 ;
反应条件
1: 2H-pyrido[2,3-d][1,3]oxazine-2,4(1H)-dione With sodium hydride in isobutyramide T=20°C; 0.5 h; 2: 1-bromo-3-methyl-butane in isobutyramide 16 h;
参考文献
Pratt, John K.; Betebenner, David A.; Donner, Pemela L.; Green, Brian E.; Kempf, Dale J.; McDaniel, Keith F.; Maring, Clarence J.; Stoll, Vincent S.; Zhang, Rong
Patent: US2004/87577 A1, 2004 ;
Location in patent: Page 40 ;
反应条件
sodium hydride in N,N-dimethyl-formamide 3 h; Ambient temperature;
参考文献
Canonne, P.; Boulanger, R.; Chantegrel, B.
Tetrahedron, 1987 , vol. 43, # 4 p. 663 - 668
参考文献
Sonnenburg, Ralf; Neda, Ion; Fischer, Axel; Jones, Peter G.; Schmutzler, Reinhard
Chemische Berichte, 1995 , vol. 128, # 6 p. 627 - 634