2-氨基-3-羟基丙酸甲酯合成路线 （共 30 条）
反应条件
1: With sodium cyanoborohydride in methanol 2: With methanol; water; sodium hydrogencarbonate
参考文献
SMITHKLINE BEECHAM CORPORATION; ANDERTON, Claire Louise; CLAPHAM, David; LAWRENCE, Ronnie Maxwell
Patent: WO2010/15626 A1, 2010 ;
Location in patent: Page/Page column 21-22 ;
WO 2010/015626 A1
反应条件
triethylamine in dichloromethane T=20°C; 17.5 h;
参考文献
Li, Xianfeng; Plattner, Jacob J.; Hernandez, Vincent; Ding, Charles Z.; Wu, Wei; Yang, Yang; Xu, Musheng
Tetrahedron Letters, 2011 , vol. 52, # 38 p. 4924 - 4926
反应条件
phosphorus pentachloride Verseifen des salzsauren Salzes des erhaltenen Methylesters durch Erhitzen mit 20prozentiger Salzsaeure auf 100grad;
参考文献
Fischer,E.; Raske
Chemische Berichte, 1907 , vol. 40, p. 3718
Chemische Berichte, 1908 , vol. 41, p. 894
反应条件
potassium carbonate; zinc(II) chloride in tetrahydrofuran T=0°C; 90 h; Inert atmosphereResolution of racemate; enantioselective reaction;
参考文献
Journal of Heterocyclic Chemistry, , vol. 49, # 5 p. 1108 - 1113,6
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 32, # 1 p. 25 - 29
反应条件
triphenyl-phosphine oxide in acetonitrile
T=20°C; 24 h;
参考文献
Morieux, Pierre; Stables, James P.; Kohn, Harold
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 19 p. 8968 - 8975
反应条件
triethylamine in 1,4-dioxane; water
0.5 h; Ambient temperature;
参考文献
Abdioui, Khalid L.; Martinez, Jean; Viallefont, Philippe; Vidal, Yves
Bulletin des Societes Chimiques Belges, 1997 , vol. 106, # 7-8 p. 425 - 432
反应条件
phosphorus pentachloride; acetyl chloride
2.5 h; 0 deg C -> rt;
参考文献
Bigge, Christopher F.; Wu, Jiang-Ping; Drummond, James R.
Tetrahedron Letters, 1991 , vol. 32, # 52 p. 7659 - 7662
反应条件
hydroxylamine in methanol
参考文献
Cordi; Lacoste; Audinot; Millan
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 10 p. 1409 - 1414
反应条件
T=35 - 40°C; lower-melting inactive form of serine anhydride;
参考文献
Fischer,E.; Suzuki
Chemische Berichte, 1905 , vol. 38, p. 4194
