N-(6,7-二氢-6-氧代-1H-嘌呤-2-基)-2-甲基丙酰胺合成路线 （共 6 条）
反应条件
triethylamine in N,N-dimethyl-formamide T=100°C; 3 h;
参考文献
Will, David W.; Breipohl, Gerhard; Langner, Dietrich; Knolle, Jochen; Uhlmann, Eugen
Tetrahedron, 1995 , vol. 51, # 44 p. 12069 - 12082
反应条件
in N,N-dimethyl-formamide T=155°C; 3 h;
参考文献
Nasr, Tamer; Taniguchi, Yosuke; Sasaki, Shigeki
Heterocycles, 2007 , vol. 71, # 12 p. 2659 - 2668
反应条件
1.1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 4 h / 60 °C 1.2: 5 h / 40 - 42 °C / Enzymatic reaction 2.1: ammonia / methanol / 10 h / 25 - 28 °C View Scheme
参考文献
Singh, Sunil K.; Sharma, Vivek K.; Olsen, Carl E.; Wengel, Jesper; Parmar, Virinder S.; Prasad, Ashok K.
Journal of Organic Chemistry, 2010 , vol. 75, # 22 p. 7932 - 7935
反应条件
1: 1.) BSA, 2.) SnCl4 / 1.) CH3CN, 80 deg C, 2.) room temperature, 30 min, 3.) CH3CN, 80 deg C, 13 h 2: 78 percent / NH3/MeOH / 24 h / Ambient temperature View Scheme
参考文献
Robins, Morris J.; Zou, Ruiming; Guo, Zhiqiang; Wnuk, Stanislaw F.
Journal of Organic Chemistry, 1996 , vol. 61, # 26 p. 9207 - 9212
反应条件
1.1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 6 h / 60 °C 1.2: 4 h / 40 - 42 °C / Enzymatic reaction 2.1: ammonia / methanol / 10 h / 25 - 28 °C View Scheme
参考文献
Singh, Sunil K.; Sharma, Vivek K.; Olsen, Carl E.; Wengel, Jesper; Parmar, Virinder S.; Prasad, Ashok K.
Journal of Organic Chemistry, 2010 , vol. 75, # 22 p. 7932 - 7935
反应条件
1: 64 percent / NaH / dimethylformamide / 2 h / 0 °C 2: 100 percent / triethylsilane; trifluoroacetic acid / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Hudson, Robert H. E.; Goncharenko, Mykhaylo; Wallman, Andrew P.; Wojciechowski, Filip
Synlett, 2005 , # 9 art. no. S07604ST, p. 1442 - 1446
