1H -吡唑-5 - 羧酸乙酯合成路线 （共 4 条）
反应条件
1: With sulfuric acid T=80°C; 16 h; 2: With sodium hydroxide in water; ethyl acetate pH=8;
参考文献
ARRAY BIOPHARMA INC.; BOYS, Mark Laurence; BRADLEY, Michael; DELISLE, Robert Kirk; HENNINGS, D. David; KENNEDY, April L.; MARMSATER, Fredrik P.; MEDINA, Matthew; MUNSON, Mark C.; RAST, Bryson; RIZZI, James P.; RODRIGUEZ, Martha E.; TOPALOV, George T.; ZHAO, Qian
Patent: WO2011/79076 A1, 2011 ;
Location in patent: Page/Page column 114 ;
反应条件
hydrazine monohydrochloride in methanol T=60°C; 6 h;
参考文献
Hanzlowsky, Andrej; Jelencic, Blanka; Recnik, Simon; Svete, Jurij; Golobic, Amalija; Stanovnik, Branko
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 3 p. 487 - 498
反应条件
hydrazine monohydrochloride 4 h; Heating;
参考文献
Martins; Freitag; Flores; Zanatta
Synthesis, 1995 , # 12 p. 1491 - 1492
反应条件
1: 62 percent / CH2Cl2 / 2 h / 20 °C 2: 76 percent / hydrazine monohydrochloride / methanol / 6 h / 60 °C View Scheme
参考文献
Hanzlowsky, Andrej; Jelencic, Blanka; Recnik, Simon; Svete, Jurij; Golobic, Amalija; Stanovnik, Branko
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 3 p. 487 - 498
