1-(2,2,2-三氟乙酰基)吲哚啉-5-磺酰氯合成路线 （共 9 条）
反应条件
chlorosulfonic acid; thionyl chloride
参考文献
Fraley, Mark E.; Arrington, Kenneth L.; Buser, Carolyn A.; Ciecko, Patrice A.; Coll, Kathleen E.; Fernandes, Christine; Hartman, George D.; Hoffman, William F.; Lynch, Joseph J.; McFall, Rosemary C.; Rickert, Keith; Singh, Romi; Smith, Sheri; Thomas, Kenneth A.; Wong, Bradley K.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 2 p. 351 - 355
反应条件
T=0 - 20°C; 2 h; Neat (no solvent);
参考文献
ANACOR PHARMACEUTICALS, INC.; HERNANDEZ, Vincent, S.; LI, Xianfeng; ZHANG, Suoming; AKAMA, Tsutomu; ZHANG, Yanchen; LIU, Yang; PLATTNER, Jacob, J.; ALLEY, Michael, Kevin Richard; ZHOU, Yasheen; NEIMAN, James, A.
Patent: WO2011/60196 A1, 2011 ;
Location in patent: Page/Page column 129 ;
反应条件
1: pyridine / CH2Cl2 / 0 °C 2: ClSO3H / 60 °C View Scheme
参考文献
ANACOR PHARMACEUTICALS, INC.; HERNANDEZ, Vincent, S.; LI, Xianfeng; ZHANG, Suoming; AKAMA, Tsutomu; ZHANG, Yanchen; LIU, Yang; PLATTNER, Jacob, J.; ALLEY, Michael, Kevin Richard; ZHOU, Yasheen; NEIMAN, James, A.
Patent: WO2011/60196 A1, 2011 ;
反应条件
ammonia; water in 1,4-dioxane
参考文献
Wyeth
Patent: US2009/48282 A1, 2009 ;
Location in patent: Page/Page column 18 ;
反应条件
1: NH3 / CH2Cl2 / 20 °C
2: NaOH / dimethylformamide / 0 - 20 °C
View Scheme
参考文献
Kim, Semi; Park, Ji Hyun; Koo, Sun-Young; Kim, Jung In; Kim, Min-Hyeung; Kim, Ji Eun; Jo, Kiwon; Geun Choi, Hwan; Lee, Sung Bae; Jung, Sang-Hun
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 6075 - 6078
参考文献
Fraley, Mark E.; Arrington, Kenneth L.; Buser, Carolyn A.; Ciecko, Patrice A.; Coll, Kathleen E.; Fernandes, Christine; Hartman, George D.; Hoffman, William F.; Lynch, Joseph J.; McFall, Rosemary C.; Rickert, Keith; Singh, Romi; Smith, Sheri; Thomas, Kenneth A.; Wong, Bradley K.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 2 p. 351 - 355
反应条件
1: NaOH
2: 95 percent / MnO2 / CH2Cl2
View Scheme
参考文献
Fraley, Mark E.; Arrington, Kenneth L.; Buser, Carolyn A.; Ciecko, Patrice A.; Coll, Kathleen E.; Fernandes, Christine; Hartman, George D.; Hoffman, William F.; Lynch, Joseph J.; McFall, Rosemary C.; Rickert, Keith; Singh, Romi; Smith, Sheri; Thomas, Kenneth A.; Wong, Bradley K.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 2 p. 351 - 355
反应条件
1: NaOH
2: 95 percent / MnO2 / CH2Cl2
3: 100 percent / DMAP
View Scheme
参考文献
Fraley, Mark E.; Arrington, Kenneth L.; Buser, Carolyn A.; Ciecko, Patrice A.; Coll, Kathleen E.; Fernandes, Christine; Hartman, George D.; Hoffman, William F.; Lynch, Joseph J.; McFall, Rosemary C.; Rickert, Keith; Singh, Romi; Smith, Sheri; Thomas, Kenneth A.; Wong, Bradley K.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 2 p. 351 - 355
反应条件
1.1: NaOH
2.1: 95 percent / MnO2 / CH2Cl2
3.1: 100 percent / DMAP
4.1: t-BuLi
4.2: 94 percent / tetrahydrofuran / -78 °C
View Scheme
参考文献
Fraley, Mark E.; Arrington, Kenneth L.; Buser, Carolyn A.; Ciecko, Patrice A.; Coll, Kathleen E.; Fernandes, Christine; Hartman, George D.; Hoffman, William F.; Lynch, Joseph J.; McFall, Rosemary C.; Rickert, Keith; Singh, Romi; Smith, Sheri; Thomas, Kenneth A.; Wong, Bradley K.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 2 p. 351 - 355
