5,6-二甲氧基-1-茚酮合成路线 （共 60 条）
反应条件
1: 49 percent / NaCN / dimethylsulfoxide / 100 °C 2: 76 percent / K2CO3; NaI / acetone View Scheme
参考文献
Leese, Mathew P.; Jourdan, Fabrice L.; Major, Meriel R.; Dohle, Wolfgang; Thomas, Mark P.; Hamel, Ernest; Ferrandis, Eric; Mahon, Mary F.; Newman, Simon P.; Purohit, Atul; Potter, Barry V. L.
ChemMedChem, 2014 , vol. 9, # 4 p. 798 - 812
反应条件
sodium cyanide in dimethyl sulfoxide T=100°C; 16 h;
参考文献
Saa, Jose M.; Marti, Catalina; Garcia-Raso, Angel
Journal of Organic Chemistry, 1992 , vol. 57, # 2 p. 589 - 594
反应条件
[TMAH][Al2Cl7] in dichloromethane Heating;
参考文献
Kemperman, Gerardus J.; Roeters, Theodorus A.; Hilberink, Peter W.
European Journal of Organic Chemistry, 2003 , # 9 p. 1681 - 1686
反应条件
1: N-bromosuccinimide, azobisisobutyronitrile / CCl4 / 1.5 h / Heating 2: bromine / CCl4 / Heating 3: 94 percent / aq. AgNO3 / acetonitrile / 1 h / Heating 4: 59 percent / dimethyl sulfoxide / 48 h / 90 - 95 °C View Scheme
参考文献
Maslak, Przemyslaw; Chopra, Anu; Moylan, Christopher R.; Wortmann, Ruediger; Lebus, Sonja; Rheingold, Arnold L.; Yap, Glenn P. A.
Journal of the American Chemical Society, 1996 , vol. 118, # 6 p. 1471 - 1481
反应条件
1: 94 percent / Hg-Zn, concd. HCl / H2O; toluene / 6 h / Heating 2: BBr3 / CH2Cl2 / 3 h / 0 - 20 °C View Scheme
参考文献
Kikumoto; Tobe; Fukami; Egawa
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 246 - 250
反应条件
1.1: potassium carbonate / methanol; H2O / Heating 1.2: 77 percent / methanol; H2O / 2.5 h / 75 °C 2.1: 31 g / H2 / palladium carbon / methanol / 2 h / 20 °C / 760.05 Torr View Scheme
参考文献
Synthetic Communications, , vol. 37, # 17 p. 2847 - 2853
反应条件
1: sodium methylate / tetrahydrofuran 2: palladium 10 on activated carbon; hydrogenchloride / ethanol; water View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 45, # 2 p. 168 - 170
反应条件
1: 95.6 percent / p-toluenesulfonic acid / toluene / 6 h / Heating 2: 90 percent / hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C View Scheme
参考文献
Siddiqui, Nadeem; Arshad, M. Faiz; Khan, Suroor A.; Ahsan, Waquar; Ali, Ruhi; Alam, M. Shamsher; Ahmed, Sharique
Medicinal Chemistry Research, 2012 , vol. 21, # 6 p. 726 - 733
反应条件
1: 78 percent / aq. hydrochloric acid; methyl nitrite / methanol / 0.25 h 2: 80 percent / formaldehyde; aq. hydrochloric acid 3: 72 percent / glacial acetic acid; hydrogen peroxide / cooling 4: 70 percent / 4 h / 200 °C 5: anhydrous aluminium chloride / chlorobenzene / 4 h / Heating 6: sodium hydroxide; Adogen 464 / H2O / 1 h View Scheme
参考文献
Ahmed, Hafiz Badar-Ud-Din; Rama, Nasim Hasan; Malana, Muhammad Aslam; Qadeer, Ghulam
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 3 p. 820 - 822
反应条件
sodium hydride in paraffin oil T=90°C;
参考文献
Wang, Xuequan; Zhang, Hongbin; Yang, Xiaodong; Zhao, Jingfeng; Pan, Chengxue
Chemical Communications, 2013 , vol. 49, # 47 p. 5405 - 5407
