5,6-二甲氧基-1-茚酮合成路线 （共 60 条）
反应条件
boron tribromide in chloroform T=-78°C; 4 h;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2008/94896 A1, 2008 ;
Location in patent: Page/Page column 13 ;
反应条件
chromium(VI) oxide in water; acetic acid
T=20°C; 72 h;
参考文献
Harig, Marco; Neumann, Beate; Stammler, Hans-Georg; Kuck, Dietmar
European Journal of Organic Chemistry, 2004 , # 11 p. 2381 - 2397
反应条件
1: 95 percent / n-butylnitrite; conc. aq. HCl / methanol / 0.5 h / 40 °C
2: H2; H2SO4 / 10percent Pd/C / acetic acid / 7 h / 2585.81 Torr
3: 2.04 g / sodium triacetoxyborohydride; Et3N / 1,2-dichloro-ethane / 24 h
View Scheme
参考文献
Haadsma-Svensson; Cleek; Dinh; Duncan; Haber; Huff; Lajiness; Nichols; Smith; Svensson; Zaya; Carlsson; Lin
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4716 - 4732
反应条件
1: sodium tetrahydroborate / methanol / 3 h / 0 - 25 °C
2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 14 h / 0 - 25 °C / |Inert atmosphere
3: palladium on activated charcoal; hydrogen / methanol; chloroform / 20 h / 25 °C
View Scheme
参考文献
Akbaba, Yusuf; Akincioglu, Akin; Goecer, Huelya; Goeksu, Sueleyman; Guelcin, Ilhami; Supuran, Claudiu T.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2014 , vol. 29, # 1 p. 35 - 42
反应条件
1: 80 percent / Zn / benzene / 4 h / Heating
2: 86 percent / H2 / 5 percent Pd/C / ethanol / 5 h / 20 °C / 2585.74 Torr
View Scheme
参考文献
Tombari, D. G.; Moglioni, A. G.; Dominici, F. P.; Iglesias, G. Y. Moltrasio de
Organic Preparations and Procedures International, 1992 , vol. 24, # 1 p. 45 - 48
反应条件
1: in methanol; toluene
T=20°C; 0.166667 h;
2: With sodium methylate in methanol; toluene
T=20 - 103°C; 2.5 h; Product distribution / selectivity;
参考文献
PLIVA ISTRAZIVANJE I RAZVOJ D.O.O.; PLIVA HRVATSKA D.O.O.; MCLEISH, Nicholas, Alistair, Maxwell
Patent: WO2007/15052 A1, 2007 ;
Location in patent: Page/Page column 14 ;
反应条件
sodium hydride in toluene
T=20°C; 0.666667 h; Heating / reflux; Product distribution / selectivity;
参考文献
PLIVA ISTRAZIVANJE I RAZVOJ D.O.O.; PLIVA HRVATSKA D.O.O.; MCLEISH, Nicholas, Alistair, Maxwell
Patent: WO2007/15052 A1, 2007 ;
Location in patent: Page/Page column 13-14 ;
反应条件
hydrogenchloride; sodium azide in water
T=0 - 20°C;
参考文献
Abate, Carmen; Selivanova, Svetlana V.; Mueller, Adrienne; Kraemer, Stefanie D.; Schibli, Roger; Marottoli, Roberta; Perrone, Roberto; Berardi, Francesco; Niso, Mauro; Ametamey, Simon M.
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 920 - 930
反应条件
1: BBr3 / CH2Cl2 / -78 - 20 °C
2: K2CO3 / dimethylformamide / 80 °C
View Scheme
参考文献
Learmonth, David A.; Bonifacio, Maria Joao; Soares-Da-Silva, Patricio
Journal of Medicinal Chemistry, 2005 , vol. 48, # 25 p. 8070 - 8078
反应条件
1: BBr3 / CH2Cl2 / -78 - 20 °C
2: K2CO3 / dimethylformamide / 80 °C
3: aq. HNO3; AcOH
4: aq. HBr; AcOH / 110 °C
View Scheme
参考文献
Learmonth, David A.; Bonifacio, Maria Joao; Soares-Da-Silva, Patricio
Journal of Medicinal Chemistry, 2005 , vol. 48, # 25 p. 8070 - 8078
