反应条件
<b>Multi-step reaction with 16 steps<br /> </b>1.1: NaH / 48 h / Heating<br />2.1: 7.95 g / Et<sub>3</sub>SiH; CF<sub>3</sub>COOH / CH<sub>2</sub>Cl<sub>2</sub> / 3 h / 0 - 20 °C<br />3.1: 81 percent / TsOH / acetone / 1 h<br />4.1: 1,4-diazabicyclo[2.2.2]octane; [RhCl(Ph<sub>3</sub>P)3] / ethanol; benzene; H<sub>2</sub>O / 18 h / Heating<br />4.2: 85 percent / mercury(II) oxide; mercury(II) chloride / acetone; H<sub>2</sub>O / 0.5 h<br />5.1: NaH / dimethylformamide / 0.25 h / 0 °C<br />5.2: 95 percent / dimethylformamide / 0 - 20 °C<br />6.1: 100 percent / hydrogen / W-2 Raney Ni / ethanol / 48 h / 0 °C / 760 Torr<br />7.1: 100 percent / 2-iodoxybenzoic acid / acetonitrile / 0.47 h / Heating<br />8.1: 77 percent / t-BuOK / diethyl ether / 0 - 20 °C<br />9.1: 31 percent / BuLi; [ZrCl<sub>2</sub>(Cp)2] / toluene; hexane / -78 - 0 °C<br />10.1: 98 percent / Et<sub>3</sub>N / tetrahydrofuran / 0 - 20 °C<br />11.1: 83 percent / 4,5-dichloro-3,6-dioxocyclohexadiene-1,2-carbonitrile / CH<sub>2</sub>Cl<sub>2</sub>; H<sub>2</sub>O / 7 h<br />12.1: 99 percent / Et<sub>3</sub>N; N,N-dimethylpyridin-4-amine / CH<sub>2</sub>Cl<sub>2</sub> / 0.33 h<br />13.1: O<sub>3</sub> / CH<sub>2</sub>Cl<sub>2</sub> / -78 °C<br />13.2: 83 percent / i-Pr<sub>2</sub>EtNH / CH<sub>2</sub>Cl<sub>2</sub> / 0.17 h / 0 °C<br />14.1: 100 percent / CeCl<sub>3</sub>*7H<sub>2</sub>O; NaBH<sub>4</sub> / ethanol / 0.67 h / 0 °C<br />15.1: 95 percent / 2,6-dimethylpyridine / CH<sub>2</sub>Cl<sub>2</sub> / 0.17 h / 0 °C<br />16.1: 100 percent / DIBAL-H / CH<sub>2</sub>Cl<sub>2</sub>; hexane / 0.25 h / -78 °C<br /> <br />
参考文献
Paquette, Leo A.; Tian, Zhenjiao; Seekamp, Christopher K.; Wang, Tony Helvetica Chimica Acta, 2005 , vol. 88, # 6 p. 1185 - 1198
