5-溴-2-(吡咯烷-1-基)吡啶合成路线 （共 3 条）
反应条件
in butan-1-ol T=75°C; 16 h; sealed tube;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.; BHARATHAN, Indu, T.; DUFFEY, Matthew, O.; ELDER, Amy, M.; GUO, Jianping; LI, Gang; REYNOLDS, Dominic; SOUCY, Francois; VOS, Tricia, J.
Patent: WO2010/65134 A1, 2010 ;
Location in patent: Page/Page column 110 ;
WO 2010/065134 A1
反应条件
4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine in dichloromethane; toluene
反应条件
tetrakis(triphenylphosphine) palladium(0); 1,8-diazabicyclo[5.4.0]undec-7-ene in water; tert-butyl alcohol
T=85°C; 4 h; Inert atmosphere;
参考文献
Zhang, Dengyou; Sun, Haifeng; Zhang, Lei; Zhou, Yu; Li, Chunpu; Jiang, Hualiang; Chen, Kaixian; Liu, Hong
Chemical Communications, 2012 , vol. 48, # 23 p. 2909 - 2911
