(4-氨基-2-氯苯基)(2-甲苯基)甲酮合成路线 （共 4 条）
反应条件
tin(ll) chloride in ethanol T=70°C; 2 h;
参考文献
Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise
Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662
反应条件
1.1: SOCl2 / toluene; dimethylformamide / 2 h / Heating 2.1: n-BuLi / hexane; tetrahydrofuran / 0.33 h / -78 °C 2.2: ZnCl2 / tetrahydrofuran; hexane / 2 h / -78 - 20 °C 2.3: 76 percent / Pd(PPh3)4 / tetrahydrofuran; hexane / 0 - 20 °C 3.1: 96 percent / SnCl2*2H2O / ethanol / 2 h / 70 °C View Scheme
参考文献
Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise
Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662
反应条件
1.1: n-BuLi / hexane; tetrahydrofuran / 0.33 h / -78 °C 1.2: ZnCl2 / tetrahydrofuran; hexane / 2 h / -78 - 20 °C 1.3: 76 percent / Pd(PPh3)4 / tetrahydrofuran; hexane / 0 - 20 °C 2.1: 96 percent / SnCl2*2H2O / ethanol / 2 h / 70 °C View Scheme
参考文献
Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise
Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662
反应条件
1: 47 percent / KOtBu / dimethylsulfoxide / 18 h / 20 °C 2: 98 percent / SnCl2*2H2O / ethanol / 2 h / 70 °C View Scheme
参考文献
Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise
Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662
