甲基(2R,4S)-4-羟基-2-哌啶羧酸酯合成路线 （共 7 条）
反应条件
palladium(II) hydroxide/carbon; palladium 10 on activated carbon; hydrogen in methanol T=20°C; 2 h;
参考文献
Molnar, Tuende; Visy, Julia; Simon, Agnes; Moldvai, Istvan; Temesvari-Major, Eszter; Doernyei, Gabor; Fekete, Erzsebet Kutine; Kardos, Julianna
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 23 p. 6290 - 6292
反应条件
1: With hydrogen; palladium on activated charcoal T=20°C; 96 h; atmospheric pressure; 2: With Ambersep 900 (OH-) in methanol T=20°C; 2 h;
参考文献
Cordero, Franca M.; Bonollo, Simona; Machetti, Fabrizio; Brandi, Alberto
European Journal of Organic Chemistry, 2006 , # 14 p. 3235 - 3241
反应条件
1.1: NEt3 / CH2Cl2 / 4.5 h / 0 - 20 °C 2.1: H2 / Pd/C / 96 h / 20 °C / atmospheric pressure 2.2: 20 mg / Ambersep 900 (OH-) / methanol / 2 h / 20 °C View Scheme
参考文献
Cordero, Franca M.; Bonollo, Simona; Machetti, Fabrizio; Brandi, Alberto
European Journal of Organic Chemistry, 2006 , # 14 p. 3235 - 3241
反应条件
1: 4-bromo-but-1-ene With (R)-1-phenyl-ethyl-amine; triethylamine in acetonitrile 2: formyl formic acid With 4 A molecular sieve in acetonitrile 3: methanol With hydrogenchloride; hydrogen; palladium dihydroxide
参考文献
Sata, Noriko U; Kuwahara, Ryuji; Murata, Yuko
Tetrahedron Letters, 2002 , vol. 43, # 1 p. 115 - 118
反应条件
1: NH3 / methanol / 2 h 2: piperidine / methanol / 2 h / Ambient temperature View Scheme
参考文献
Rutjes, Floris P. J. T.; Veerman, Johan J. N.; Meester, Wim J. N.; Hiemstra, Henk; Schoemaker, Hans E.
European Journal of Organic Chemistry, 1999 , # 5 p. 1127 - 1135
反应条件
hydrogenchloride; hydrogen; palladium dihydroxide Multistep reaction;
参考文献
Bellier, Bruno; Da Nascimento, Sophie; Meudal, Herve; Gincel, Edith; Roques, Bernard P.; Garbay, Christiane
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 11 p. 1419 - 1424
反应条件
sodium hydroxide in 1,4-dioxane
参考文献
Barton, Patrick; Brough, Steven; Evans, Richard; Luckhurst, Christopher A.; Mochel, Tobias; Perry, Matthew W. D.; Rigby, Aaron; Sanganee, Hitesh; Sisson, Adam; Springthorpe, Brian; Bahl, Ash; Bowers, Keith; Riley, Robert J.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6688 - 6693,6
