4-(4-甲基苯氧基)苯甲酸合成路线 （共 10 条）
反应条件
in dimethyl sulfoxide
参考文献
US5521173 A1, ;
US 5521173 A
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 100 °C 2: sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; water / tetrahydrofuran; tert-butyl alcohol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1788 - 1792
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 100 °C 2: sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; water / tetrahydrofuran; tert-butyl alcohol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1788 - 1792
反应条件
sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; water in tetrahydrofuran; tert-butyl alcohol Pinnick oxidation;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1788 - 1792
参考文献
Yakugaku Zasshi, , vol. 61, p. 129,132
Chem.Abstr., , p. 7906
反应条件
1: copper-powder / 155 - 210 °C 2: ethanolic KOH-solution View Scheme
参考文献
Yakugaku Zasshi, , vol. 61, p. 129,132
Chem.Abstr., , p. 7906
反应条件
1: copper-powder / 155 - 210 °C 2: ethanolic KOH-solution View Scheme
参考文献
Yakugaku Zasshi, , vol. 61, p. 129,132
Chem.Abstr., , p. 7906
反应条件
1: copper (I)-bromide; aqueous hydrobromic acid / Diazotization 2: copper-powder / 155 - 210 °C 3: ethanolic KOH-solution View Scheme
参考文献
Yakugaku Zasshi, , vol. 61, p. 129,132
Chem.Abstr., , p. 7906
反应条件
1: 1,2-dibromo-ethane; bromine / Irradiation.Sonnenlicht 2: CHCl3 / Erhitzen des Reaktionsprodukts mit wss. Essigsaeure View Scheme
参考文献
Ito; Shibanuma
Pharmaceutical Bulletin, 1957 , vol. 5, p. 619
反应条件
1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 24 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C
View Scheme
参考文献
Carrasco, Marta P.; Newton, Ana S.; Goncalves, Lidia; Gois, Ana; Machado, Marta; Gut, Jiri; Nogueira, Fatima; Haenscheid, Thomas; Guedes, Rita C.; Dos Santos, Daniel J.V.A.; Rosenthal, Philip J.; Moreira, Rui
European Journal of Medicinal Chemistry, 2014 , vol. 80, p. 523 - 534
