DL-α-氨基噻吩-2-醋酸合成路线 （共 14 条）
反应条件
4-methoxy-N-(1-(naphthalen-2-yl)ethylidene)aniline; ammonium formate in methanol T=80°C; 12 h; Inert atmosphere; chemoselective reaction;
参考文献
Talwar, Dinesh; Salguero, Noemi Poyatos; Robertson, Craig M.; Xiao, Jianliang
Chemistry - A European Journal, 2014 , vol. 20, # 1 p. 245 - 252
反应条件
hydrogenchloride 1 h; Heating;
参考文献
Cali; Begtrup
Synthesis, 2002 , # 1 p. 63 - 66
参考文献
O'Donnell, Martin J.; Falmagne, Jean-Bernard
Tetrahedron Letters, 1985 , vol. 26, # 6 p. 699 - 702
反应条件
1: 750 mg / aq. HCl / diethyl ether / 12 h / 20 °C 2: 84 percent / aq. HCl / 1 h / Heating View Scheme
参考文献
Synthesis, , # 1 p. 63 - 66
反应条件
methanol; potassium cyanide; ammonium chloride; ammonia Reagens 4: Wasser; Behandeln des Reaktionsprodukts mit wss. Salzsaeure;
参考文献
Zhurnal Obshchei Khimii, , vol. 26, p. 2595,2599; engl. Ausg. S. 2893, 2896
反应条件
triethylamine in tetrahydrofuran; water T=20°C; 15 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1695961 A1, 2006 ;
Location in patent: Page/Page column 63 ;
反应条件
triethylamine in tetrahydrofuran; water T=20°C; 15 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1695961 A1, 2006 ;
Location in patent: Page/Page column 63 ;
反应条件
chiral stationary phase including isopropyl-functionalized CF6 in methanol; acetic acid; triethylamine; acetonitrile T=20°C; Purification / work up;
参考文献
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; ARMSTRONG, Daniel, W.; PING, Sun; BREITBACH, Zachary, S.; WANG, Chunlei
Patent: WO2010/148191 A2, 2010 ;
Location in patent: Page/Page column 45-49; 61 ;
反应条件
chiral stationary phase including isopropyl-functionalized CF6 in methanol; acetic acid; triethylamine; acetonitrile T=20°C; Purification / work up;
参考文献
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; ARMSTRONG, Daniel, W.; PING, Sun; BREITBACH, Zachary, S.; WANG, Chunlei
Patent: WO2010/148191 A2, 2010 ;
Location in patent: Page/Page column 45-49; 61 ;
反应条件
1: With sodium tetrahydroborate; iodine in tetrahydrofuran T=0°C; 18 h; Heating / reflux; 2: With potassium hydroxide; water 4 h;
参考文献
Chen, Li; Chen, Shaoqing
Patent: US2006/4045 A1, 2006 ;
Location in patent: Page/Page column 14 ;
US 20060004045 A1
