DL-α-氨基噻吩-2-醋酸合成路线 （共 14 条）
反应条件
trifluoroacetic anhydride in toluene
参考文献
American Cyanamid Company
Patent: US5492925 A1, 1996 ;
反应条件
triethylamine in tetrahydrofuran; water
T=20°C; 15 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1695961 A1, 2006 ;
Location in patent: Page/Page column 63 ;
反应条件
1: LiAlH4 / tetrahydrofuran / Heating
2: aq. NaHCO3 / tetrahydrofuran / 20 °C
3: Et3N / CH2Cl2 / 20 °C
View Scheme
参考文献
Kim, Semi; Park, Ji Hyun; Koo, Sun-Young; Kim, Jung In; Kim, Min-Hyeung; Kim, Ji Eun; Jo, Kiwon; Geun Choi, Hwan; Lee, Sung Bae; Jung, Sang-Hun
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 6075 - 6078
反应条件
1: LiAlH4 / tetrahydrofuran / Heating
2: aq. NaHCO3 / tetrahydrofuran / 20 °C
3: Et3N / CH2Cl2 / 20 °C
4: NaOH / dimethylformamide / 0 - 20 °C
View Scheme
参考文献
Kim, Semi; Park, Ji Hyun; Koo, Sun-Young; Kim, Jung In; Kim, Min-Hyeung; Kim, Ji Eun; Jo, Kiwon; Geun Choi, Hwan; Lee, Sung Bae; Jung, Sang-Hun
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 6075 - 6078
