2-(甲基硫代)吡啶并[2,3-d]嘧啶-7(8h)-酮合成路线 （共 8 条）
反应条件
Sodium hydride in methanol 1 h; Heating / reflux;
参考文献
EP1364950 A1, ;
Page/Page column 22 ;
EP 1364950 A1
反应条件
in N-ethyl-N,N-diisopropylamine
参考文献
Booth, Richard John; Chatterjee, Arindam; Malone, Thomas Charles
Patent: US2004/224958 A1, 2004 ;
US 20040224958 A1
Title/Abstract Full Text Show Details
Warner-Lambert Company
Patent: US6498163 B1, 2002 ;
US 6498163 B1
反应条件
1: 75 percent / tetrahydrofuran / 3 h / Heating 2: 45 percent / N,N-diisopropylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 24 p. 4606 - 4616
反应条件
1: 100 percent / MnO2 / CHCl3 / 20 °C 2: 75 percent / tetrahydrofuran / 3 h / Heating 3: 45 percent / N,N-diisopropylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 24 p. 4606 - 4616
反应条件
1: 79 percent / Et3N; aq. NH4OH / tetrahydrofuran / 2.5 h / 20 °C 2: 76 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 20 °C 3: 100 percent / MnO2 / CHCl3 / 20 °C 4: 75 percent / tetrahydrofuran / 3 h / Heating 5: 45 percent / N,N-diisopropylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 24 p. 4606 - 4616
反应条件
1: 76 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 20 °C 2: 100 percent / MnO2 / CHCl3 / 20 °C 3: 75 percent / tetrahydrofuran / 3 h / Heating 4: 45 percent / N,N-diisopropylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 24 p. 4606 - 4616
反应条件
1.1: NaH / dimethylformamide / 50 °C 1.2: dimethylformamide / 50 °C 2.1: (+/-)-trans-2-(phenylsulfonyl)-3-phenyloxaziridine / CHCl3 / 20 °C View Scheme
参考文献
Barvian; Boschelli; Cossrow; Dobrusin; Fattaey; Fritsch; Fry; Harvey; Keller; Garrett; La; Leopold; McNamara; Quin; Trumpp-Kallmeyer; Toogood; Wu; Zhang
Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4606 - 4616
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=20°C;
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURON, Sergio, G.; VOLLRATH, Benedikt; WADE, Warren
Patent: WO2011/156646 A2, 2011 ;
Location in patent: Page/Page column 134 ;
WO 2011/156646 A2
