N-(2-苯基苯基)乙酰胺合成路线 （共 68 条）
反应条件
CyGemPhos; water; palladium diacetate; caesium carbonate in 1,4-dioxane
T=150°C; Buchwald-Hartwig coupling; 24 h;
参考文献
Falk, Florian C.; Froehlich, Roland; Paradies, Jan
Chemical Communications, 2011 , vol. 47, # 39 p. 11095 - 11097
反应条件
aluminium trichloride in benzene
3 h; Ambient temperature;
参考文献
Tashiro, Masashi; Fukuda, Yasuhisa; Yamato, Takehiko
Journal of Organic Chemistry, 1983 , vol. 48, # 11 p. 1927 - 1928
反应条件
palladium diacetate; copper(II) bis(trifluoromethanesulfonate); silver(l) oxide in toluene
T=120°C; 24 h;
参考文献
Chu, Jean-Ho; Tsai, Shiang-Lin; Wu, Ming-Jung
Synthesis, 2009 , # 22 art. no. F11509SS, p. 3757 - 3764
反应条件
1.1: iron; acetic acid / ethanol / 1 h / 100 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; acetonitrile / 100 °C / Inert atmosphere
View Scheme
参考文献
Kajiyama, Daichi; Inoue, Keisuke; Ishikawa, Yuichi; Nishiyama, Shigeru
Tetrahedron, 2010 , vol. 66, # 52 p. 9779 - 9784
反应条件
1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / ethylene glycol dimethyl ether / 3 h / |Reflux
2: 10 Pd/C; hydrogen / methanol / 12 h / 20 °C / 3750.38 Torr
3: lithium hydroxide hydrate / dichloromethane / 2.08 h / 0 - 20 °C
View Scheme
参考文献
Weitz, Evan A.; Chang, Jennifer Y.; Rosenfield, Adam H.; Pierre, Valerie C.
Journal of the American Chemical Society, 2012 , vol. 134, # 39 p. 16099 - 16102,4
反应条件
palladium diacetate; copper(II) bis(trifluoromethanesulfonate); silver(l) oxide in 1,2-dichloro-ethane
T=90°C; 18 h; regioselective reaction;
参考文献
Zhang, Guo-Zhen; Chen, Cheng-Qun; Feng, Xin-Hua; Huang, Guo-Sheng
Journal of Chemical Sciences, 2010 , vol. 122, # 2 p. 149 - 155
反应条件
1: N-acetyl-3,4,5,6-tetrahydroaniline With methylethyl sulfide; silver(I) acetate; palladium diacetate in ethylene glycol dimethyl ether
T=100°C; 3.5 h;
2: iodobenzene With copper(II) bis(trifluoromethanesulfonate) in ethylene glycol dimethyl ether
T=100°C;
参考文献
Kim, Jinhee; Moon, Youngtaek; Lee, Suhyun; Hong, Sungwoo
Chemical Communications, 2014 , vol. 50, # 24 p. 3227 - 3230
反应条件
1: Inert atmosphere
2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; acetonitrile / 100 °C / Inert atmosphere
View Scheme
参考文献
Kajiyama, Daichi; Inoue, Keisuke; Ishikawa, Yuichi; Nishiyama, Shigeru
Tetrahedron, 2010 , vol. 66, # 52 p. 9779 - 9784
反应条件
palladium diacetate; polymethylhydrosiloxane in diethyl ether; acetonitrile
P=7355.08 Torr;
参考文献
Kikukawa, Kiyoshi; Totoki, Takatoshi; Wada, Fumio; Matsuda, Tsutomu
Journal of Organometallic Chemistry, 1984 , vol. 270, # 3 p. 283 - 288
反应条件
1: 83 percent
2: 79 percent / aluminum chloride / benzene / 3 h / Ambient temperature
View Scheme
参考文献
Tashiro, Masashi; Fukuda, Yasuhisa; Yamato, Takehiko
Journal of Organic Chemistry, 1983 , vol. 48, # 11 p. 1927 - 1928
