3-碘-5-(三氟甲基)-2-吡啶胺合成路线 （共 4 条）
反应条件
1: With sulfuric acid; iodine; acetic acid; periodic acid in water T=85°C; 18 h; 2: With sodium hydroxide in water T=20°C; pH=10 - 14;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/79346 A1, 2008 ;
Location in patent: Page/Page column 58 ;
WO 2008/079346 A1
反应条件
1: With sulfuric acid; water 1 h; Heating / reflux; 2: With sodium hydroxide; sodium hydrogencarbonate in water T=20°C;
参考文献
GRUNENTHAL GMBH
Patent: US2009/156593 A1, 2009 ;
Location in patent: Page/Page column 18 ;
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in tetrahydrofuran T=0 - 20°C; 0.5 h;
参考文献
WO2008/79346 A1, ;
Page/Page column 58; 59 ;
WO 2008/079346 A1
反应条件
1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate in N,N-dimethyl-formamide
T=110°C; 6 h;
参考文献
SANOFI-AVENTIS
Patent: US2009/298865 A1, 2009 ;
Location in patent: Page/Page column 8 ;
US 20090298865 A1
