potassium acetate in water; N,N-dimethyl-formamide T=25°C; 1 h;

Multistep reaction.;

Multistep reaction.;

1: Methyltriphenylphosphonium bromide With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine in tetrahydrofuran 0.25 h; 2: 4-OHCC6H4OTIPS in tetrahydrofuran 12 h; Heating / reflux;

in tetrahydrofuran; water

1.1: 87 percent / Ti(OEt)4 / CH2Cl2 / 5 h / 40 °C 2.1: NaHMDS / diethyl ether / 0.67 h / -78 °C 2.2: 78 percent / diethyl ether / 1 h / -78 °C 3.1: 83 percent / trifluoroacetic acid / methanol / 1 h / 0 °C 4.1: 83 percent / DCC / tetrahydrofuran / 12 h / 0 °C 5.1: 94 percent / trifluoroacetic acid / CH2Cl2 / 1 h / 0 °C 6.1: 80 percent / DCC; HOBt / 24 h / 0 - 20 °C 7.1: 96 percent / aq. lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 8.1: 2,6-lutidine / CH2Cl2 / 1 h / 20 °C 9.1: 80 percent / aq. potassium carbonate / tetrahydrofuran; methanol / 0.5 h / 20 °C 10.1: DIPEA; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 2.5 h / 20 °C 10.2: 82 percent / DMAP / benzene / 8 h 11.1: 90 percent / TBAF / tetrahydrofuran / 0.17 h / 0 °C View Scheme