1: malonic acid di(tert-butyl)-ester With potassium tert-butylate; palladium diacetate in tetrahydrofuran; toluene 0.583333 h; 2: 3-(bromo)-quinoline in tetrahydrofuran; toluene T=180°C; 0.05 h; Microwave irradiation; 3: With trifluoroacetic acid in toluene T=100°C; 3 h;

sulfuric acid T=70 - 80°C; 3 h;

1: 89 percent / H2O / HgSO4, conc. H2SO4 / acetone / 18 h 2: 1.) KOH, HONH2*HCl / 1.) MeOH, water, 2.) MeOH, water, 21 h, reflux 3: 55 percent / PCl5 / diethyl ether / 20 h / Ambient temperature; adding 0-5 deg C 4: 50 percent H2SO4 / 3 h / 70 - 80 °C View Scheme

1: 1.) KOH, HONH2*HCl / 1.) MeOH, water, 2.) MeOH, water, 21 h, reflux 2: 55 percent / PCl5 / diethyl ether / 20 h / Ambient temperature; adding 0-5 deg C 3: 50 percent H2SO4 / 3 h / 70 - 80 °C View Scheme

1: 55 percent / PCl5 / diethyl ether / 20 h / Ambient temperature; adding 0-5 deg C 2: 50 percent H2SO4 / 3 h / 70 - 80 °C View Scheme