4-三甲基甲硅烷-3-丁炔-1-醇合成路线 （共 22 条）
反应条件
pyridine in dichloromethane T=-78°C; 0.333333 h;
参考文献
Hanessian, Stephen; Tremblay, Martin
Organic Letters, 2004 , vol. 6, # 25 p. 4683 - 4686
反应条件
1: <MeP(OPh)3>I / CH2Cl2; dimethylformamide 2: ethanol 3: NaH / dimethylsulfoxide; tetrahydrofuran View Scheme
参考文献
Fallis,A.G. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973 , p. 743 - 749
反应条件
(i) <MeP(OPh)3>I, (ii) /BRN= 1766823/, NaH; Multistep reaction;
参考文献
Fallis,A.G. et al.
Journal of the Chemical Society [Section] D: Chemical Communications, 1969 , p. 924 - 925
反应条件
hydrogen bromide T=0°C; 2 h; Yield given;
参考文献
Magnus, Philip; Quagliato, Dominick
Journal of Organic Chemistry, 1985 , vol. 50, # 10 p. 1621 - 1626
反应条件
Yield givenMultistep reaction;
参考文献
Smith, Adrian L.; Stevenson, Graeme I.; Swain, Christopher J.; Castro, Jose L.
Tetrahedron Letters, 1998 , vol. 39, # 45 p. 8317 - 8320
参考文献
Murray,T.F.; Norton,J.R.
Journal of the American Chemical Society, 1979 , vol. 101, p. 4107 - 4119
反应条件
1: 93 percent / 1.) n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 1 h; 2.) rt, 6 h
2: 90 percent / LiBr / acetone / 12 h / 25 °C
3: 1.) Cl(H)ZrCp2; 2.) AlCl3 / 1.) benzene, 25 deg C, 12 h; 2.) CH2Cl2, 0 deg C, 1 h
View Scheme
参考文献
Negishi,E.; Boardman,L.D.; Sawada,H.
Journal of the American Chemical Society, 1988 , vol. 110, p. 5383
反应条件
trimethylaluminum; diisobutylaluminium hydride
1.) CH2Cl2, 2.) CH2Cl2 23 deg C, 16 h; Yield given. Multistep reaction;
参考文献
Wakamatsu, Kuni; Nonaka, Tsuyoshi; Okuda, Yasuhiro; Tueckmantel, Werner; Oshima, Koichiro; et al.
Tetrahedron, 1986 , vol. 42, # 16 p. 4427 - 4436
反应条件
diisobutylaluminium hydride in hexane
T=23°C; 16 h; Yield given. Yields of byproduct given;
参考文献
Ma, Shengming; Liu, Fang; Negishi, Ei-Ichi
Tetrahedron Letters, 1997 , vol. 38, # 22 p. 3829 - 3832
参考文献
Chen, Cheng-Yi; Lieberman, David R.; Larsen, Robert D.; Reamer, Robert A.; Verhoeven, Thomas R.; Reider, Paul J.; Cottrell, Ian F.; Houghton, Peter G.
Tetrahedron Letters, 1994 , vol. 35, # 38 p. 6981 - 6984
