3-(3-三氟甲基苯基)丙醛合成路线 （共 17 条）
反应条件
1: With sodium tetrahydroborate in ethanol T=20°C; 24 h; 2: With ethanol; water in ethyl acetate Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES, LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2006/125026 A2, 2006 ;
Location in patent: Page/Page column 25 ;
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Lednicer; Emmert
Journal of medicinal chemistry, 1968 , vol. 11, # 6 p. 1258 - 1262
反应条件
1: With sodium tetrahydroborate; boric acid T=20°C; 14.5 h; 2: With hydrogenchloride in hexane; water T=20°C; pH=1 - 3; 3.5 h;
参考文献
TYCHE INDUSTRIES LIMITED; NARAYANA, Rao Mutyala; RAMADAS, Chavakula; SRINIVASA, Rao Chennupati; SANDEEP, Gokaraju
Patent: WO2014/16847 A1, 2014 ;
Location in patent: Page/Page column 5; 9 ;
反应条件
1: sodium tris(acetoxy)borohydride / methanol / 2 h / 20 °C 2: hydrogenchloride / ethyl acetate / 1 h / 10 °C / pH 2 View Scheme
参考文献
DIPHARMA FRANCIS s.r.l.
Patent: US2011/124917 A1, 2011 ;
反应条件
1: in tetrahydrofuran 0.25 h; 2: With sodium tris(acetoxy)borohydride; acetic acid in tetrahydrofuran 2 h; 3: With sodium carbonate in dichloromethane; water Product distribution / selectivity;
参考文献
WO2008/68625 A2, ;
Page/Page column 18 ;
反应条件
sodium tris(acetoxy)borohydride in methanol T=20°C; 2 h;
参考文献
US2011/124917 A1, ;
Page/Page column 4 ;
反应条件
methanol; sodium tris(acetoxy)borohydride T=20°C; 2 h;
参考文献
EP2327684 A1, ;
Page/Page column 6-7 ;
