1: 2-methylindan-1-one With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 2 h; Inert atmosphere; 2: chloro-trimethyl-silane in tetrahydrofuran; hexane T=-78 - 20°C; Inert atmosphere;

1.1: LDA / tetrahydrofuran / 0.33 h / -78 °C 1.2: 76 percent / tetrahydrofuran / 12 h 2.1: LDA / tetrahydrofuran / 0.33 h / -78 °C 2.2: 70 percent / tetrahydrofuran / 3 h View Scheme

hydrogen; Pd-BaSO4 in toluene 48 h;

Sc(DS)3 in water T=20°C; 6 h;