4-氨基-1H-咪唑-5-羧酸乙酯合成路线 （共 16 条）
参考文献
Cook; Thomas
Journal of the Chemical Society, 1950 , p. 1884,1886
反应条件
hydrazine hydrate
72 h; Ambient temperature;
参考文献
Scheiner; Frank; Giusti; et al.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 6 p. 1817 - 1824
反应条件
1: 39.2 percent / 50percent HBF4 / NaNO2 / H2O / 4 h / -60 - -40 °C / Irradiation
2: 1) aq.NaNO2 / 1) 2N HCl (ice-cold) 2) 10percent Na2CO3 (ice-cold)
3: 65.5 percent / formamidinesulfinic acid (FASA) / NEt3 / methanol; H2O / 20 h / 45 - 50 °C
View Scheme
参考文献
Takahashi, Kazuyuki; Kirk, Kenneth L.; Cohen, Louis A.
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 1951 - 1954
反应条件
1: 39.2 percent / 50percent HBF4 / NaNO2 / H2O / 4 h / -60 - -40 °C / Irradiation
2: 1) aq.NaNO2 / 1) 2N HCl (ice-cold) 2) 10percent Na2CO3 (ice-cold)
3: 65.5 percent / formamidinesulfinic acid (FASA) / NEt3 / methanol; H2O / 20 h / 45 - 50 °C
4: 53 percent / 50percent HBF4 / aq.NaNO2 / 3 h / -60 - -40 °C / Irradiation
View Scheme
参考文献
Takahashi, Kazuyuki; Kirk, Kenneth L.; Cohen, Louis A.
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 1951 - 1954
反应条件
1: 39.2 percent / 50percent HBF4 / NaNO2 / H2O / 4 h / -60 - -40 °C / Irradiation
2: 1) aq.NaNO2 / 1) 2N HCl (ice-cold) 2) 10percent Na2CO3 (ice-cold)
3: 65.5 percent / formamidinesulfinic acid (FASA) / NEt3 / methanol; H2O / 20 h / 45 - 50 °C
4: 53 percent / 50percent HBF4 / aq.NaNO2 / 3 h / -60 - -40 °C / Irradiation
5: 81 percent / NEt3 / CH2Cl2 / 2 h / Ambient temperature
6: NaBH4 / propan-1-ol / Ambient temperature
View Scheme
参考文献
Takahashi, Kazuyuki; Kirk, Kenneth L.; Cohen, Louis A.
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 1951 - 1954
反应条件
hydrogenchloride; sodium nitrite in water
T=0°C;
参考文献
Smith, Matthew R.; Blake, Alexander J.; Hayes, Christopher J.; Stevens, Malcolm F. G.; Moody, Christopher J.
Journal of Organic Chemistry, 2009 , vol. 74, # 24 p. 9372 - 9380
