potassium permanganate; silica gel in acetonitrile T=20°C; 1.5 h;

1: 4-pyridinecarbonitrile With sodium methylate in methanol T=20°C; 8 h; 2: 3-aminopropionaldehyde diethylacetal in methanol; acetic acid 0.5 h; Reflux; 3: With hydrogenchloride in methanol; water; acetic acid 3 h; Reflux;

ammonium hydroxide in ethanol; water 6 h; Heating;

Irradiation; Yield given. Yields of byproduct given;

triethylamine in methanol 72 h; Ambient temperatureIrradiation;