3-氯苯并(B)噻吩-2-羧酸合成路线 （共 8 条）
反应条件
sodium hydroxide 4 h; Heating;
参考文献
Sidorenko, T.N.; Terent'eva, G.A.; Raida, V.S.; Andrienko, O.S.; Savinykh, Yu.V.; Aksenov, V.S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , vol. 18, # 12 p. 1246 - 1250
Khimiya Geterotsiklicheskikh Soedinenii, 1982 , vol. 18, # 12 p. 1618 - 1622
反应条件
potassium carbonate in methanol Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 20 p. 4793 - 4807
反应条件
copper in various solvent(s) T=220°C;
参考文献
Bauer, L. N.; Ermilova, E. V.; Aksenov, V. S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , p. 112
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 1 p. 123 - 124
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
参考文献
Fuchs, Ferdinand C.; Eller, Gernot A.; Holzer, Wolfgang
Molecules, 2009 , vol. 14, # 9 p. 3814 - 3832
反应条件
1: hydrogenchloride; LiAlH4 / tetrahydrofuran; methanol 2: TPAP; NMO / silica gel / dichloromethane View Scheme
参考文献
ALLERGAN, INC.
Patent: US2012/45420 A1, 2012 ;
反应条件
1: With borane in tetrahydrofuran T=0 - 20°C; 2: With water in tetrahydrofuran
参考文献
CELGENE CORPORATION
Patent: WO2008/115516 A2, 2008 ;
Location in patent: Page/Page column 71-72 ;
反应条件
copper in quinoline
5 h; Heating;
参考文献
Sidorenko, T.N.; Terent'eva, G.A.; Raida, V.S.; Andrienko, O.S.; Savinykh, Yu.V.; Aksenov, V.S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , vol. 18, # 12 p. 1246 - 1250
Khimiya Geterotsiklicheskikh Soedinenii, 1982 , vol. 18, # 12 p. 1618 - 1622
反应条件
1: 23 percent / benzene; diethyl ether / 3 h / -30 °C
2: 1) N2H4*H2O, 2) KOH, 3) HJ / 1) N2H4*H2O, diethyleneglycol, 140 deg C, 1.5 h, 2) KOH, 180 deg C, 2 h
View Scheme
参考文献
Savinov, G. L.; Savinykh, Yu. V.; Aksenov, V. S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 1 p. 27 - 29
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 1 p. 33 - 35
