2,3-二氨基-5-氟吡啶合成路线 （共 5 条）
反应条件
1: With 5 palladium on charcoal; hydrogen in tetrahydrofuran; methanol T=20°C; 2 h; 2: With trimethylsilyl ethanol in tetrahydrofuran; methanol T=110°C; 10 h;
参考文献
Shionogi and Co., Ltd.; Tonogaki, Keisuke; Ino, Akira; Kojima, Eiichi; Katou, Manabu; Iwatsu, Masafumi; Tanaka, Nobuyuki; Fujioka, Masahiko
Patent: US2013/184240 A1, 2013 ;
Location in patent: Paragraph 0710; 0715; 0716 ;
反应条件
1: With MP-carbonate in tetrahydrofuran 1 h; 2: With hydrogen; palladium 10 on activated carbon in ethanol P=760.051 Torr;
参考文献
WO2007/16087 A2, ;
Page/Page column 54 ;
WO 2007/016087 A2
反应条件
hydrogenchloride in ethanol; water
参考文献
AstraZeneca AB
Patent: US6265415 B1, 2001 ;
US 6265415 B1
反应条件
1.1: hydrogen; platinum(IV) oxide / tetrahydrofuran; methanol / 1 h 2.1: hydrogen; 5 palladium on charcoal / tetrahydrofuran; methanol / 2 h / 20 °C 2.2: 10 h / 110 °C View Scheme
反应条件
1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 7 h / |Reflux 2.1: hydrogen; platinum(IV) oxide / tetrahydrofuran; methanol / 1 h 3.1: hydrogen; 5 palladium on charcoal / tetrahydrofuran; methanol / 2 h / 20 °C 3.2: 10 h / 110 °C View Scheme
