4-氯-7-环戊基-7H-吡咯并[2,3-d]嘧啶合成路线 （共 3 条）
反应条件
1: 4-chloro-7H-pyrrolo[2,3-d]-pyrimidine With sodium hydride in DMF (N,N-dimethyl-formamide) T=0°C; 0.5 h; 2: cyclopentyl-bromide in DMF (N,N-dimethyl-formamide) T=20 - 60°C; 4 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2005/47289 A1, 2005 ;
Location in patent: Page/Page column 38 ;
反应条件
sodium hydride; potassium carbonate in toluene T=110°C; 24 h;
参考文献
Sobolov, Susan B.; Sun, Jianmin; Cooper, Beth A.
Tetrahedron Letters, 1998 , vol. 39, # 32 p. 5685 - 5688
反应条件
1: NaH / tetrahydrofuran 2: 17 percent / NaH, K2CO3 / toluene / 24 h / 110 °C View Scheme
参考文献
Sobolov, Susan B.; Sun, Jianmin; Cooper, Beth A.
Tetrahedron Letters, 1998 , vol. 39, # 32 p. 5685 - 5688
