3 - [（3 -氨基- 4 -甲基苯甲酰）吡啶-2基氨基]丙酸乙酯合成路线 （共 14 条）
反应条件
sodium hydroxide in tetrahydrofuran T=50°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/275824 A1, 2011 ;
Location in patent: Page/Page column 5 ;
反应条件
1: With 1,1'-carbonyldiimidazole in isopropanol acetate T=20°C; 4 h; 2: With acetic acid in isopropanol acetate 2 h; Reflux;
参考文献
INTERQUIM, S.A.; HERNÁNDEZ GALLEGO, Santos; MARQUILLAS OLONDRIZ, Francisco; POMARES MARCO, Marta
Patent: WO2014/12880 A1, 2014 ;
Location in patent: Page/Page column 16; 17 ;
反应条件
1.1: CDI / tetrahydrofuran / 50 °C 1.2: tetrahydrofuran / 24 h / Heating 2.1: glacial acetic acid / 1 h / Heating View Scheme
参考文献
Hauel, Norbert H.; Nar, Herbert; Priepke, Henning; Ries, Uwe; Stassen, Jean-Marie; Wienen, Wolfgang
Journal of Medicinal Chemistry, 2002 , vol. 45, # 9 p. 1757 - 1766
反应条件
1: With 1-propanephosphonic acid cyclic anhydride; N-ethyl-N,N-diisopropylamine in tetrahydrofuran; ethyl acetate
T=20°C; 1.5 h;
2: With acetic acid
T=90°C; Product distribution / selectivity;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/71743 A1, 2007 ;
Location in patent: Page/Page column 19 ;
