2,3-二氟-4-乙氧基苯硼酸合成路线 （共 4 条）
反应条件
1: 1-ethoxy-2,3-difluorobenzene With n-butyllithium in tetrahydrofuran T=-70°C; 2 h; Inert atmosphere; 2: boric acid trimethyl ester in tetrahydrofuran T=-70 - 20°C; 16 h; 3: With water; hydrogenchloride in tetrahydrofuran
参考文献
JNC Corporation; Chisso Petrochemical Corporation
Patent: EP2399896 A1, 2011 ;
Location in patent: Page/Page column 36 ;
反应条件
1: 1-bromo-4-ethoxy-2,3-difluorobenzene With n-butyllithium in tetrahydrofuran T=-70°C; 2 h; Inert atmosphere; 2: boric acid trimethyl ester in tetrahydrofuran T=-70 - 20°C; 16 h; 3: With hydrogenchloride in tetrahydrofuran; water
参考文献
JNC Corporation; JNC Petrochemical Corporation
Patent: EP2484658 A1, 2012 ;
Location in patent: Page/Page column 42 ;
反应条件
1.1: sodium hydroxide / tetrabutylammomium bromide / water / 6 h / 80 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere 2.2: 16 h / -70 - 20 °C View Scheme
反应条件
1.1: sodium hydroxide; tetrabutylammomium bromide / water / 6 h / 80 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere 2.2: 16 h / -70 - 20 °C View Scheme
