3-氯-N-(3-甲氧基苯基)丙酰胺合成路线 （共 10 条）
反应条件
sodium hydrogencarbonate in dichloromethane T=20°C; 4 h;
参考文献
Ge, Hai-Xia; Wang, Li-Chen; Jiang, Zhen-Zhou; Ni, Sheng-Liang
Arzneimittel-Forschung/Drug Research, 2006 , vol. 56, # 10 p. 673 - 677
反应条件
in benzene Ambient temperature;
参考文献
Pohloudek-Fabini; Schroepl
Die Pharmazie, 1968 , vol. 23, # 10 p. 561 - 566
反应条件
1: With AlCl3, aluminium chloride T=155 - 165°C; 4 h; 2: With methanol; sodium hydroxide in water T=20°C; pH=7; 1 h; Heating / reflux; Product distribution / selectivity;
参考文献
Naddaka, Vladimir; Davidi, Guy; Klopfer, Eyal; Arad, Oded; Kaspi, Joseph
Patent: US2006/79690 A1, 2006 ;
Location in patent: Page/Page column 6 ;
反应条件
AlCl3, aluminium chloride in N,N-dimethyl acetamide T=140 - 150°C; Friedel Crafts Alkylation; 2.75 h;
参考文献
UNICHEM LABORATORIES LIMITED
Patent: WO2007/94009 A1, 2007 ;
Location in patent: Page/Page column 6 ;
反应条件
1: With AlCl3, aluminium chloride T=155 - 165°C; 4 h; 2: With methanol; sodium hydroxide in water T=20°C; pH=7; 1 h; Heating / reflux; Product distribution / selectivity;
参考文献
Naddaka, Vladimir; Davidi, Guy; Klopfer, Eyal; Arad, Oded; Kaspi, Joseph
Patent: US2006/79690 A1, 2006 ;
Location in patent: Page/Page column 6 ;
参考文献
O'Neill, Brian Thomas; Nagel, Arthur Adam; Humphrey, John Michael; Sobolov-Jaynes, Susan Beth; Chappie, Thomas Allen; Vincent, Lawrence Albert; Arnold, Eric Platt; Huang, Jianhua
Patent: US2003/87925 A1, 2003 ;
US 20030087925 A1
反应条件
1: 61.5 percent / N,N-dimethylacetamide; aluminium trichloride / 2 h / 150 - 160 °C 2: 83 percent / NaOH / ethanol / 2.5 h / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 56, # 10 p. 673 - 677
反应条件
1: AlCl3, aluminium chloride; N,N-dimethyl acetamide / 4 h / 140 °C 2: N-bromosuccinmide / N,N-dimethyl-formamide / 9 h / 0 °C View Scheme
参考文献
Hu, Qingzhong; Yin, Lina; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 16 p. 7080 - 7089
反应条件
trichlorophosphate
T=75°C; 2 h;
参考文献
Meth-Cohn, Otto; Rhouati, Salah; Tarnowski, Brian; Robinson, Andrew
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1537 - 1543
反应条件
1.1: AlCl3, aluminium chloride / N,N-dimethyl acetamide / 140 - 150 °C
2.1: potassium carbonate / water; acetone / 1 h / 20 °C
2.2: 16 h / 20 °C
3.1: potassium iodide / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere
View Scheme
参考文献
Pai; Samel
Asian Journal of Chemistry, 2011 , vol. 23, # 4 p. 1655 - 1660
