2-氯-N-苯基-丙酰胺合成路线 （共 20 条）
反应条件
1-methyl-1H-imidazole; N,N,N',N,-tetramethylethylenediamine; potassium carbonate in acetonitrile
T=0 - 5°C; 1 h;
参考文献
Nakatsuji, Hidefumi; Morimoto, Mami; Misaki, Tomonori; Tanabe, Yoo
Tetrahedron, 2007 , vol. 63, # 48 p. 12071 - 12080
反应条件
activated K60 silica gel in toluene
T=110°C; 24 h;
参考文献
Comerford, James W.; Clark, James H.; MacQuarrie, Duncan J.; Breeden, Simon W.
Chemical Communications, 2009 , # 18 p. 2562 - 2564
反应条件
aluminium trichloride in 1,2-dichloro-ethane
16 h;
参考文献
Sonawane; Pol; Nanjundiah; Sudalai
Journal of Chemical Research - Part S, 1998 , # 2 p. 90 - 91
反应条件
phosphorus pentachloride; benzene
und behandelt es mit Wasser;
参考文献
Bischoff; Walden
Justus Liebigs Annalen der Chemie, 1894 , vol. 279, p. 123
参考文献
Bischoff; Walden
Justus Liebigs Annalen der Chemie, 1894 , vol. 279, p. 123
反应条件
in benzene
Ambient temperature;
参考文献
Pohloudek-Fabini; Schroepl
Die Pharmazie, 1968 , vol. 23, # 10 p. 561 - 566
参考文献
Chattaway
Journal of the Chemical Society, 1902 , vol. 81, p. 639,641
参考文献
Chattaway
Journal of the Chemical Society, 1902 , vol. 81, p. 639,641
参考文献
Bischoff; Walden
Justus Liebigs Annalen der Chemie, 1894 , vol. 279, p. 123
反应条件
1: AlCl3, aluminium chloride / 4 h / 150 °C
2: dichloromethane / 5 h / -10 - 20 °C
3: sodium hydroxide / 10 h / |Reflux; |Inert atmosphere
4: hypophosphorous acid; hydrogenchloride; sodium nitrite / water / -7 - 20 °C
View Scheme
参考文献
KANDULA, Mahesh
Patent: WO2013/168003 A1, 2013 ;
