n-(4-三氟甲氧基苯基)氨基甲酸叔丁酯合成路线 （共 9 条）
参考文献
Leroux, Frederic; Castagnetti, Eva; Schlosser, Manfred
Journal of Organic Chemistry, 2003 , vol. 68, # 12 p. 4693 - 4699
反应条件
1: in tetrahydrofuran T=0 - 20°C; 2: With ammonium chloride in tetrahydrofuran; diethyl ether; water
参考文献
Carter, Percy H.; Cherney, Robert J.; Batt, Douglas G.; Brown, Gregory D.; Duncia, John V.; Gardner, Daniel S.; Yang, Michael G.
Patent: US2005/54626 A1, 2005 ;
Location in patent: Page/Page column 38 ;
US 20050054626 A1
反应条件
in tetrahydrofuran T=80°C; 3 h;
参考文献
Aventis Pharma S.A.
Patent: US6369221 B1, 2002 ;
Location in patent: Page column 18 ;
反应条件
1: With tert.-butyl lithium in tetrahydrofuran; pentane T=-50°C; 3 h; 2: With carbon tetrabromide in tetrahydrofuran; pentane T=-75°C; Further stages.;
参考文献
Bellezza, Francesca; Cipiciani, Antonio; Ruzziconi, Renzo; Spizzichino, Sara
Journal of Fluorine Chemistry, 2008 , vol. 129, # 2 p. 97 - 107
反应条件
1: tert-butyl N-(4-trifluoromethoxyphenyl)carbamate With tert.-butyl lithium in tetrahydrofuran; pentane T=-50°C; 2 h; 2: carbon dioxide in tetrahydrofuran; pentane T=25°C;
参考文献
Leroux, Frederic; Castagnetti, Eva; Schlosser, Manfred
Journal of Organic Chemistry, 2003 , vol. 68, # 12 p. 4693 - 4699
反应条件
1.1: t-BuLi / pentane; tetrahydrofuran / 2 h / -50 °C 1.2: 81 percent / pentane; tetrahydrofuran / 25 °C 2.1: 96 percent / CF3COOH / CH2Cl2 / 2 h / 25 °C View Scheme
参考文献
Schlosser, Manfred; Castagnetti
European Journal of Organic Chemistry, 2001 , # 21 p. 3991 - 3997
反应条件
1: tert-butyl N-(4-trifluoromethoxyphenyl)carbamate With tert.-butyl lithium in tetrahydrofuran; pentane
T=-50°C; 2 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; pentane
T=25°C;
参考文献
Leroux, Frederic; Castagnetti, Eva; Schlosser, Manfred
Journal of Organic Chemistry, 2003 , vol. 68, # 12 p. 4693 - 4699
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 6 h / -75 °C
1.2: 85 percent / tetrahydrofuran; hexane / 0.75 h / -75 °C
2.1: aq. HBr / 0.25 h / Heating
2.2: 88 percent / aq. NaNO2; HBr; CuBr / 0.75 h / Heating
View Scheme
参考文献
Leconte, Stephane; Ruzziconi, Renzo
Journal of Fluorine Chemistry, 2002 , vol. 117, # 2 p. 167 - 172
反应条件
hydrogenchloride; sec.-butyllithium in tetrahydrofuran
参考文献
Carter, Percy; Cherney, Robert
Patent: US2003/60459 A1, 2003 ;
US 20030060459 A1
