1: N-(tert-butoxycarbonyl)-4-(trifluoromethyl)aniline With N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran T=-30 - 20°C; 4.5 h; 2: With n-butyllithium in tetrahydrofuran; hexane T=-30°C; 4.5 h; 3: N,N-dimethyl-formamide With hydrogenchloride more than 3 stages;
1: N-(tert-butoxycarbonyl)-4-(trifluoromethyl)aniline With tert.-butyl lithium in tetrahydrofuran T=-40°C; 2: N,N-dimethyl-formamide in tetrahydrofuran
参考文献
Hewawasam, Piyasena; Chen, Nathan; Ding, Min; Natale, Joanne T.; Boissard, Christopher G.; Yeola, Sarita; Gribkoff, Valentin K.; Starrett, John; Dworetzky, Steven I.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 7 p. 1615 - 1618
