1-(2-(4-(氯甲基)苯氧基)乙基)氮杂烷合成路线 （共 4 条）
反应条件
1: With hydrogenchloride in tetrahydrofuran T=0°C; 2: With thionyl chloride in tetrahydrofuran T=50°C;
参考文献
Wyeth
Patent: EP1159267 B1, 2004 ;
Location in patent: Page 11 ;
反应条件
1.1: K2CO3 / dimethylformamide / 120 °C 2.1: NaBH4 / methanol / 20 °C 3.1: tetrahydrofuran / Heating 4.1: HCl (gas) / tetrahydrofuran / 0 °C 4.2: SOCl2 / tetrahydrofuran / 50 °C View Scheme
参考文献
Ji, Qinggang; Gao, Jie; Wang, Junbo; Yang, Chunhao; Hui, Xin; Yan, Xueming; Wu, Xihan; Xie, Yuyuan; Wang, Ming-Wei
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 11 p. 2891 - 2893
反应条件
1.1: NaBH4 / methanol / 20 °C 2.1: tetrahydrofuran / Heating 3.1: HCl (gas) / tetrahydrofuran / 0 °C 3.2: SOCl2 / tetrahydrofuran / 50 °C View Scheme
参考文献
Ji, Qinggang; Gao, Jie; Wang, Junbo; Yang, Chunhao; Hui, Xin; Yan, Xueming; Wu, Xihan; Xie, Yuyuan; Wang, Ming-Wei
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 11 p. 2891 - 2893
反应条件
1.1: tetrahydrofuran / Heating 2.1: HCl (gas) / tetrahydrofuran / 0 °C 2.2: SOCl2 / tetrahydrofuran / 50 °C View Scheme
参考文献
Ji, Qinggang; Gao, Jie; Wang, Junbo; Yang, Chunhao; Hui, Xin; Yan, Xueming; Wu, Xihan; Xie, Yuyuan; Wang, Ming-Wei
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 11 p. 2891 - 2893
